Previous appointments:

Institute for Genomics and Systems Biology, The University of Chicago

Center for Computational Science and Engineering, University of California, Davis

Research interests:

Recently published and ongoing projects are in the areas of:

  • Complex systems, Networks, and, Statistical physics

- Networks and information theory
- Quantum entanglement on networks
- Networks and game theory
- New measures in networks and their implications

Innovative applications of networks, e.g. in Information retrieval, image processing,
   and n
on-invasive diagnostics, mutagenesis, phage resistance etc.
Phase transitions and critical phenomena

  • Communication, competition and co-operation in Microbial systems (Theory and Experiments)

              - Antimicrobial resistance
Phage-bacteria interactions and dynamics

  • Computational Systems Biology

              - Structure, function and dynamics of biological macromolecules 
Microbial systems


Address: Physical Sciences
Unified Academic Campus
Bose Institute
EN-80, Sector V
Bidhan Nagar
Kolkata - 700 091, India
E-Mail: soumen[at]
Phone: +91-33-25693232


For more details please visit our Lab website

Our interdisciplinary lab in the Dept. of physics is associated with two institutional research programmes on: (i) complex systems, and, (ii) physical and environmental sciences.

We study a wide variety of physical and biological systems by applying tools from statistical physics, network science, non-linear dynamics and game theory. We also design and conduct experiments in parallel with mathematical modelling towards achieving a better understanding of biological systems. Recently published and ongoing projects are listed here

Recent work by students of our lab has been published in interdisciplinary, physics and life science journals like Bioinformatics (Oxford), Europhysics Letters (EPL), Physical Review E (APS), Applied and Environmental Microbiology (ASM), Scientific Reports (Nature), and Frontiers in Physics (Frontiers). Our invited contributions have appeared in publications like Methods in Molecular Biology and Advances in Applied Microbiology.


Patents granted as Principal Inventor:
A system and method for analyzing videos of application or function for feature identification of the videos and related application or function [ Patent No. 472279 (2023) ]
Soumen Roy et al.

Copyrights registered as Principal Author:

Software for analyzing videos of application or function for feature identification of the videos and related application or function Registration number: [ SW-10052 (2018) ] 
Soumen Roy et al.


*Corresponding / Co-corresponding author

An ab initio information-theoretic approach to proteins and protein-ligand interactions (2024)

Deep NathRajdeep Kaur Grewal, Devrani Mitra* and Soumen Roy*

Assessing combinatorial diversity of Aureochrome bZIPs through genome-wide screening (2024)

Cells Tissues Organs [Karger], 213, 133-146 (2024) [Invited]  bioRxiv 2022.06.05.494858
Madhurima Khamaru, Deep Nath, Devrani Mitra* and Soumen Roy*

Mutations, mathematics, and medicine: Probing phages (Invited review, submitted)
Swati Sharma, Akash Gupta and Soumen Roy*

Modeling plaque formation: Phages on bacteria (Invited article, submitted)
Deep Nath, Swati Sharma and Soumen Roy*

Network approach to mutagenesis sheds insight on phage resistance in mycobacteria

Bioinformatics [Oxford],  37,  213-220 (2021)        PDF
Saptarshi SinhaSourabh SamaddarSujoy Das Gupta and Soumen Roy*

Summary    Popular Coverage at Research Matters     Popular Coverage at Daily Hunt   

Scale-free networks may not necessarily witness cooperation
Euro Physics Letters [EPL], 134, 60002 (2021)       arXiv:2101.01167 
Deep Nath, Saptarshi Sinha and Soumen Roy*

Topology dependent payoffs can lead to escape from prisoner’s dilemma 
European Physical Journal B, 94, 80 (2021)     arXiv:2006.14593 
Saptarshi Sinha, Deep Nath and Soumen Roy*

Mass testing and proactiveness affect epidemic spreading [Invited]
Special issue on "Emerging Trends in Modeling and Analysis of Complex Systems"
Journal of the Indian Institute of Science, 101, 371-380 (2021)        arXiv:2008.10387
Saptarshi Sinha, Deep Nath and Soumen Roy*

Modeling phage-bacteria dynamics
Methods in Molecular Biology, 2131, 309-327 (2020) [Springer]
Saptarshi SinhaRajdeep Kaur Grewal and Soumen Roy*

Residue interaction dynamics in Vaucheria aureochrome1 light-oxygen-voltage: Bridging theory and experiments
Proteins: Structure, Function, and Bioinformatics [Wiley], 88, 1660-1674 (2020)
Anwesha Deb, Rajdeep Kaur Grewal, Soumen Roy* and Devrani Mitra*

A pedestrian review of games on structured populations [Invited review]    PDF
International Journal of Advances in Engineering Sciences and Applied Mathematics [Springer], 11, 138-152 (2019) 
Saptarshi Sinha, Susanta Ghosh and Soumen Roy*

Role of a 19S proteasome subunit - PSMD10 Gankyrin in neurogenesis of human neuronal progenitor cells
International Journal of Stem Cells, 12, 463-473, (2019) 
Indrajit Sahu, Padma Nanaware, Minal Mane,  Soumen Roy* and Prasanna Venkatraman*

Topologically inspired walks on randomly connected landscapes with correlated fitness
Frontiers in Physics [Frontiers], 6: 138 (2018)
Rajdeep Kaur Grewal, Saptarshi Sinha and Soumen Roy*

Modeling bacteria-phage interactions and implications for phage therapy
Advances in Applied Microbiology [Academic Press], 103, 103-141 (2018) 
Saptarshi SinhaRajdeep Kaur Grewal and Soumen Roy*

Dynamics of Mycobacteriophage-Mycobacterial host interaction - evidence for secondary mechanisms for host lethality 
Applied and Environmental Microbiology [ASM], 82, 124-133 (2016)        PDF        Supplementary Information
Sourabh SamaddarRK GrewalS Sinha, S Ghosh, Soumen Roy* and Sujoy Das Gupta*

Selected as an article of significant interest by the Editors for AEM Spotlight

Using complex networks towards information retrieval and diagnostics in multidimensional imaging
Scientific Reports [Nature] 5: 17271 (2015)     arxiv:1506.02602     PDF         Supplementary Information
Soumya Jyoti Banerjee, Mohammad Azharuddin, Debanjan Sen, Smruti Savale, Himadri Datta, Anjan Dasgupta and Soumen Roy*

Slow poisoning and destruction of networks: Edge proximity and its implications for biological and infrastructure networks 
Physical Review E [APS]  91 022807 (2015)     arxiv:1409.8268    PDF 
Soumya Jyoti BanerjeeSaptarshi Sinha and Soumen Roy*

Mapping networks of light-dark transition in LOV photoreceptors 
Bioinformatics [Oxford] 31 3608-3616 (2015)    Supplementary Information 
Rajdeep Kaur GrewalDevrani Mitra and Soumen Roy

Modeling proteins as residue interaction networks [Invited review]
Protein & peptide letters 22 923-933 (2015)
Rajdeep Kaur Grewal and Soumen Roy*

Perspectives in systems biology
Editorial for special issue
Systems and Synthetic Biology [Springer] (2014) 8: 1-2    PDF
Soumen Roy*

Efficient scheduling using complex networks
Osamu YamaguchiSoumen Roy* and Raissa M. D'Souza

Systems biology beyond degree, hubs and scale-free networks: the case for multiple metrics in complex networks
Systems and Synthetic Biology [Springer] (2012)  631-34     arxiv:1205.2318     PDF 
Soumen Roy*

Analysis of early host responses for asymptomatic disease detection and management of speciality crops
Critical Reviews in Immunology 30 277-289 (2010) 
A. M. Dandekar et. al. 

Resilience and rewiring of the passenger airline networks in the United States
Physical Review E  82  056101 (2010)  arxiv:0901.0774     PDF 

Daniel R. Wuellner,  Soumen Roy* and Raissa M. D'Souza 

Strong associations between microbe phenotypes and their network architecture
Physical Review E  (Rapid)  80  040902(R) (2009)  arxiv:0901.0775      PDF 
Soumen Roy* and Vladimir Filkov

Modeling and verifying a broad array of network properties
Europhysics Letters  86 (2009) 28003   arxiv:0805.1489     PDF
Vladimir FilkovZachary M. SaulSoumen RoyRaissa M. D'Souza and Prem Devanbu
"Graphlet arrival model" has been covered in the book: An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks (Chapman & Hall/CRC Computational Biology Series)

Network growth with feedback
Physical Review E  (Rapid)  78  045101(R) (2008)  arxiv:0805.4020    PDF  
Raissa M. D'Souza and Soumen Roy*

Motion of a random walker in a quenched power law correlated velocity field
Physical Review E  73  026106 (2006)   cond-mat/0511008   PDF 
Soumen Roy* and Dibyendu Das

Giant coherence in driven systems
J. Stat. Mech. (2006)  P09012    cond-mat/0511519    PDF
Soumen Roy*, Debasis Dan and A. M. Jayannavar

Is small-world network disordered?
Physics Letters A  352  13 (2006)    cond-mat/0409012   PDF 
Soumen Roy* and Somendra M. Bhattacharjee

Enhanced Thermodynamic efficiency in time asymmetric ratchets
J. Stat. Mech. (2005) P04012    cond-mat/0412303  PDF
Raishma Krishnan,  Soumen Roy* and A. M. Jayannavar

Invited book chapters:

"Allostery and networks" in "Advances in Biology"
Nova, New York, USA (2023)
 Swati Sharma, Deep Nath, and Soumen Roy*

"Systems biology in plant cells and their organelles" in "Plant cells and their organelles"
John Wiley & Sons Ltd., UK (2017). Editors: Dashek and Miglani
Rajdeep Kaur GrewalSaptarshi Sinha and Soumen Roy*
        [Book Review: "Perhaps the most important chapter in this book ...", Elizabeth Friar, Crop Science (2017) 57 3360-3361 ]        

"Complex networks and systems biology" in "Systems and Synthetic Biology
Springer Netherlands (2015).  Editors: Singh and Dhar
Ushasi RoyRajdeep Kaur Grewal and Soumen Roy*

"Networks, metrics and systems biology" in "A systems theoretic approach to systems and synthetic biology I: models and system characterizations
Springer Netherlands (2014). Editors: Kulkarni, Stan and Raman
Soumen Roy*

Contributed book chapters:

"The network route to biological complexity" in BIOMAT 2015 - Proceedings of the 15'th International Symposium on Mathematical and Computational Biology - IIT Roorkee 
World Scientific (2016). Editor: Mondaini 
Soumya Jyoti BanerjeeRajdeep Kaur GrewalSaptarshi Sinha and Soumen Roy*

View More


  • Guest Editor, Special Issue on Statistical physics and complex systems, Indian Journal of Physics (Springer), 2023
  • Reviewer, (Mathematics & Computer Science Panel), National Research, Development and Innovation Office, Hungary, Since 2022
  • Academic Editor, PLOS ONE, 2018--present
  • Regular Associate, International Centre for Theoretical Physics (UNESCO), Trieste, Italy, 2017--present
  • Editor, Special Issue, Systems and Synthetic Biology (Springer), 2014
  • Hon. Assoc. Editor, Indian Journal of Physics (Springer), 2012--present
  • Member, Planning Commission Task Force on Systems and Synthetic Biology, Govt of India, 2011


Statistical physics
   Ph.D.                                                                                                    2023
Computer programming with python
   Ph.D.                                                                                                    2023

Research ideology and research ethics
   Ph.D.                                                                                                    2023

   Ph.D.                                                                                                    2022

Numerical methods
   Ph.D.                                                                                                    2022

Computational and Systems Biology (609)

   Integrated Ph.D. in Life Sciences                                                2020-2021

Statistical Physics - II

   Integrated Ph.D. in Physical Sciences                                        2019-2020

Statistical Physics - I

   Integrated Ph.D. in Physical Sciences                                        2017-2018

   Integrated Ph.D. in Physical Sciences                                        2016-2017

   Integrated Ph.D. in Physical Sciences                                        2015-2016

Computation and numerical techniques - I

   Integrated Ph.D. in Physical Sciences                                        2014-2015

   Integrated Ph.D. in Physical Sciences                                        2013-2014

Dynamical systems (Tools of systems biology - II)

   Integrated Ph.D. in Life Sciences (Bose Institute)                        2014-2015

   Integrated Ph.D. in Life Sciences (Bose Institute)                        2013-2014

Networks (Computational and systems biology)

   Integrated Ph.D. in Life Sciences                                                2014-2015

   Integrated Ph.D. in Life Sciences                                                2013-2014

Concepts of approximations (Tools of systems biology - I)

   Integrated Ph.D. in Life Sciences                                                2014-2015

   Integrated Ph.D. in Life Sciences                                                2013-2014

   Integrated Ph.D. in Life Sciences                                                2012-2013


Image Name Designation Department Campus Contact number Email
profile image Arijit Roy Junior Research Fellow Physics Unified
profile image Ramnarayan Bera Junior Research Fellow Physics Unified
profile image Swati Sharma Junior Research Fellow Physics Unified


Former Doctoral Fellows:

Deep Nath --  Submitted Ph.D. Thesis in March 2024
Ph. D. Registration [ Theoretical physics ]  University of Calcutta
Ph.D. Thesis Title: Information, games and graphs

Deep Nath

Dr. Saptarshi Sinha
--  Current / next affiliation: University of California, San Diego, USA 
Ph. D. [ Microbiology (Systems Biology) ]  University of Calcutta
Ph.D. Thesis Title: Competition and cooperation in microbes

Dr. Rajdeep Kaur Grewal  --  Current / next affiliation: Ohio State University, USA
Ph. D. [ Applied Mathematics (Networks) ] University of Calcutta 
Ph.D. Thesis Title: Studies on Biological Networks

Dr. Soumya Jyoti Banerjee  --  Current / next affiliation: TCS Research and Innovation
Ph. D. [ Applied Mathematics (Networks)University of Calcutta 
Ph.D. Thesis Title: Structural aspects of complex networks and their applications

Group News:

For more details please visit our Group website 

Special Issue on "Statistical Physics and Complex Systems"

Indian Journal of Physics (Springer)

Guest Editors: Deepak Dhar and Soumen Roy