Swati Gupta Bhattacharya

Swati Gupta Bhattacharya
Senior Professor

Research interests:

  1. Aerobiology and Palynology
  2. Allergen biology: structure, function, and immunology of Allery eliciting molecules
  3. Allergens: for improvement of Diagnosis and therapy
  4. Biomarkers of Allergy

Contact:

Address: Division of Plant Biology
Main Campus
Bose Institute
93/1, A. P. C. Road
Kolkata - 700 009, India
E-Mail: swati[at]jcbose.ac.in
Phone: +91-33-23031129

Research:

Aerobiology:

To identify and record the prevalence and distribution of common airborne pollen grains and fungal spores in different ambient environments and their relationship with allergy related health hazards.

Palynology:

Study of pollen morphology and ultra-structural characters in solving disputed plant taxonomical and phylogenetical problems.

Allergy and Immunology:

 

  1. Identification of allergenically significant pollen, spores, and foods and assessment of their allergenic potential by in-vivo and in-vitro tests.

  2. Proteomics, serological studies, and purification of allergenic proteins from potent allergenic sources.

  3. Identification, purification, cloning, expression and immunological study of the recombinant allergen for molecular diagnosis.

  4. Understanding the 3D structure of the allergens by in-silico and biophysical studies.

  5.  Understanding the epitope (IgE and T-cell) structure and features of allergens.

  6. Strategies to produce genetically modified hypo-allergens for desensitization (immunotherapy) of allergic patients.






  Projects undertaken and ongoing:

  a) Funding from CSIR

“Diagnosis of mold allergy among inhabitants of urban and rural peoples of the gangetic plane of west Bengal through aerobiological and immunochemical studies.”
 

   b) Funding from DBT

1. “Studies on mould spore diversity as environmental allergen in outdoor and indoor environments of urban and rural areas of Agartala, Tripura. (Co-PI: Dr. T. K. Ghose)

2. Development of Molecular Diagnostics and Immunotherapeutic Vaccines for Prawn and Brinjal Allergy (Co-PI: Dr. Sudipto Saha)


   c) Funding from ICMR.

Systematic discovery of biomarkers of asthma caused by common environmental allergens using human plasma proteomics, cytokine profiling and network biology – a systems approach to drug discovery. (Co-PI: Dr. Sudipto Saha)


d) Funding from World Wildlife Funds (WWF):



 

Publications:

  1. Sircar G, Jana K, Dasgupta A, Saha S, and Gupta Bhattacharya S. (2016). Epitope Mapping of Rhi o 1 and Generation of a Hypoallergenic Variant -A candidate molecule for fungal allergy vaccines. J Biol. Chem. Journal of Biological Chemistry (ASBMB). 291(34):18016-29   Impact Factor – 4.573

  2. Ghosal K, Saha B, and Gupta Bhattacharya S. (2016). Clinical and immuno-proteomic approach on Lantana camara pollen allergy-a major health hazard. Allergy Asthma Clin Immunol 2016 Jul 28;12:33. doi: 10.1186/s13223-016-0135-z. Impact Factor – 2.283

  3. Dey D, Saha B, Sircar G, Ghosal K, Gupta Bhattacharya S. (2016) Mass spectrometry-based identification of allergens from Curvularia pallescens, a prevalent aerospore in India. Biochim Biophys Acta. (Proteins and Proteomics) Jul;1864(7):869-79. doi: 10.1016/j.bbapap.2016.03.012. Impact Factor -2.74

  4. Saha B, Sircar G, Pandey N, and Gupta Bhattacharya S (2015) Mining novel allergens from Coconut Pollen employing manual denovo sequencing and homology driven proteomics. J.Proteome Res. 1021/acs.jproteome.5b00657 Publication Date (Web): October 1, 2015:1-40  Impact Factor-4.173

  5. Ghosh N#, Sircar G#, Saha B, Pandey N, Gupta Bhattacharya S (2015) Search for Allergens from the Pollen Proteome of Sunflower (Helianthus annuus L.): A Major Sensitizer for Respiratory Allergy Patients. Plos One, 10(9): e0138992. doi:10.1371/ journal.pone.0138992Impact Factor-3.057  (#- equal contribution)

  6. Sircar G#, Saha B#, Jana T#, Dasgupta A, Gupta Bhattacharya S*. and S.Saha.(2015). DAAB: a manually curated database of allergy and asthma biomarkers). Clinical & Experimental Allergy. 45, 1259–1261. (#- equal contribution) Impact factor- 5.587

  7. Sircar, G., Saha, B., Mandal, R. S., Pandey, N., Saha, S., & Gupta Bhattacharya, S. (2015). Purification, Cloning and Immuno-Biochemical Characterization of a Fungal Aspartic Protease Allergen Rhi o 1 from the Airborne Mold Rhizopus oryzaePloS one10(12). Impact factor -3.057

  8. Ghosh D, Mueller GA, Schramm G, Petersen A, Haas H and Gupta Bhattacharya S.(2014). Primary identification, biochemical characterization, and immunologic properties of the allergenic pollen cyclophilin Cat r 1. J Biol Chem  289(31), 21374- 21385. Impact factor – 4.573

  9. Dey, D., Ghosh, N., Pandey, N., & Gupta Bhattacharya S. 2014. A Hospital-Based Survey on Food Allergy in the Population of Kolkata, India. International Archives of Allergy and Immunology(Karger Publ. Switzerland) 164(3), 218-221.   Impact factor-2.677

  10. Sircar G, Chakrabarti HS, Saha B, and Gupta-Bhattacharya S. Identification of aero-allergens from Rhizopus oryzae: An immunoproteomic approach." Journal of proteomics 77 (2012): 455-468. Impact factor- 4.008

  11. Ghosh D, Chakraborty P, Gupta J, Biswas, A,. Roy I, Das S and Gupta Bhattacharya S. 2012. Associations between Pollen Counts, Pollutants, and Asthma-Related Hospital Admissions in a High-Density Indian Metropolis. Journal of Asthma, 2012; 49(8): 792–799.Informa Healthcare USA, Inc. Impact Factor- 1.5 

  12. Das S and Gupta Bhattacharya S. 2012. Monitoring and assessment of airborne fungi in Kolkata, India, by viable and non-viable air sampling methods. Environmental monitoring and assessment. 184:4671–4684. Impact Factor- 1.4 

  13. Mondal H.A., Chakraborti D., Majumder P., Roy P, Roy A, Gupta Bhattacharya S.and Das S.2011.Allergenicity Assessment of Allium sativum Leaf Agglutinin, a Potential Candidate Protein for Developing Sap Sucking Insect Resistant Food Crops. PLoS ONE 6(11): e27716. doi:10.1371/journal.pone.0027716. Impact Factor: 3.057

  14. Mandal J, Roy I, Gupta-Bhattacharya S. 2011. Clinical and Immunobiochemical characterization of airborne  Peltophorum pterocarpum (Yellow Gulmohar tree) pollen:a dominant avenue tree of India. Annals of Allergy Asthma and Immunology. (Elsevier)106, 412– 420. Impact Factor:2.8 

  15. Ghosh D, Chakraborty, P, Gupta J, Biswas A and Gupta Bhattacharya S. 2010. Asthma related hospital admissions in Kolkata, an Indian megacity: Role of ambient aeroallergens and inorganic Pollutants. Allergy.65(6)795-799. Impact Factor: 6.2 

  16. Mandal J, Manna P, Chakraborty P, Roy I and Gupta-Bhattacharya S. Clinical and immunobiochemical characterization of airborne Delonix regia (Gulmohar tree) pollen and cross reactivity studies with Peltophorum pterocarpum pollen: Two dominant avenue trees from Eastern India. Annals of Allergy Asthma and Immunology. 2009; 103(6); 515-524.  Impact Factor: 2.8 

  17. Das S and Gupta-Bhattacharya STrichoderma harzianum: occurrence in the air and clinical significance. Aerobiologia. 2009.(25):137-145. Impact Factor -1.5 

  18. Chakraborty P, Mandal J, Sarkar E, Chowdhury I and Gupta Bhattacharya S. Clinico-immunochemical studies on airborne Areca catechu L. pollen, a probable risk factor in emergency asthma hospitalization from Eastern India. International Archives of Allergy and ImmunologyKarger Publishers, Switzerland. 2009.;149:305-314. Impact Factor- 2.4 

  19. Ghosh D and Gupta- Bhattacharya, S. Structural insight into protein T1, the non-allergenic member of the Bet v 1 allergen family - an in silico analysis. Molecular Immunology, Elsevier, UK. 2008, 45, 456-462. Impact Factor- 2.8

  20. Chakraborty, P., Ghosh, D., Chowdhury.I., Chatterjee, S. Chanda,S.; Gupta- Bhattacharya, S. 2005. Aerobiological and immunochemical studies on Carica papaya L. pollen: an aeroallergen from India. Allergy, 60:920-926, Blackwell Publ. Impact Factor -6.2 

  21. Adhikari, A., Sen, M.; Gupta-Bhattacharya, S. and Chanda, S. (2004). Airborne viable, non-viable and allergenic fungi in a rural agricultural area of India: a 2-year study at five outdoor sampling stations. Science of the Total Environment, 326:121-139. Elsevier, UK.  Impact Factor -3.2      

  22. Ghosh D, Roy. D and Gupta-Bhattacharya. S, 2003. Homology   Modeling of Allergenic Cyclophilins: IgE binding site and structural basis of cross reactivity. Biochemical and Biophysical Research Communications. 307, 422-429. Elsevier, UK . Impact Factor -2.4     

  23. Chakraborty, P., Chowdhury, I., Gupta- Bhattacharya, S., Gupta, S., Sengupta, D.N. and Chanda S. 1999. Clinico- immunological studies on the pollen grains of Phoenix sylvestrisRoxb., a common aeroallergen from Calcutta, India.   Allergy.54: 985-989. European College of Allergy and Clinical Immunology, Sweden. Impact Factor -6.2   

  24. Chowdhury, I., Chakraborty, P., Gupta Bhattacharya, S. and Chanda, S. 1998. Allergenic relationship among four common and dominant airborne palm pollen grains from Eastern India. Clinical and Experimental Allergy 28:977-983. Blackwell Science Ltd., UK . Impact Factor -5.0                               

Review:

  1. Sircar G#, Saha S#, Gupta Bhattacharya S*, and Saha S. "Allergic asthma biomarkers using systems approaches." Frontiers in genetics 4 (2014): 308.

(*- corresponding author and #- equal contribution)

Book Chapter

  1. Sircar, G., Sarkar, D., Bhattacharya, S. G*., & Saha, S. 2014. Allergen Databases. Methods in Mol. Biol. Immunoinformatics (Humana Press) (pp. 165-181). Springer New York. Impact factor-1.9

  2. Sircar, G., Saha, B., Bhattacharya, S. G*., & Saha, S. 2014. In Silico Prediction of Allergenic Proteins. Methods in Mol. Biol. Immunoinformatics (Humana Press) (pp. 375-388). Springer New York.  Impact factor-1.9

  3. Ghosh D and Gupta Bhattacharya S. Allergen Bioinformatics: Recent Trends and Developments.  Book chapter in "Bioinformatics", 2011. ISBN 978-953-307-281-4.Intech open  access Publisher.

*- corresponding author 

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Recognition:

    Teaching:

    I am involved in teaching the integrated MSc.-PhD students and Ph.D. course work for the research scholars on the following topics such as (i) Plant Proteomics, (ii) Pollen biology, (iii) Allergy and Immunology

    Present:

    Image Name Designation Department Campus Contact number Email
    profile image Bijoya Karmakar SRF Division of Plant Biology Main 23501131 bijoya
    profile image Koyel SenGupta SRF Division of Plant Biology Main 23031131 koyel
    profile image Moumita Bhowmik SRF Division of Plant Biology Main 23031129 moumita
    profile image Moumita Biswas Sarkar JRF Division of Plant Biology Main moumit100@gmail.com
    profile image Nandini Ghosh SRF(I) Division of Plant Biology Main 23031129 nandini
    profile image Sangeeta Roy SRF Division of Plant Biology Main 23031131 sangeeta

    Former:

    Research fellows:

    1. Gaurab Sircar

    2. Debarati Dey

    3. Nandini Ghosh

    4. Sangeeta Roy

    5. Koyel SenGupta

    6. Moumita Bhowmik

    7. Moumita Biswas Sarkar

    8. Sukhendu Maity

    9. Subham Bhakta

    Supporting staffs:

    1. Chanchal Chakraborty, Technical Officer

    2. Soumyo Shubhra Gupta, Technical Assistant

    3. Asish Bera, Lab attendant

    Group News: