Previous appointments:

University of Liege, Belgium, 1990, 1994

Research interests:

Cellular and molecular biology of mycobacteria

Contact:

Address: Department of Chemistry
Main Campus
Bose Institute
93/1, A. P. C. Road
Kolkata - 700 009, India
E-Mail: joyoti[at]jcbose.ac.in
Phone: +91-33-23031153

Research:

  • The major focus is to understand the biology of tuberculosis infections.

    Specific interests:

    Integrated experimental and bioinformatic system level characterization of (a) transcriptional networks and (b) histone modifications and their role in Mycobacterium    tuberculosis -macrophage     interactions.  The system-levels analyses will provide a framework for identifying key transcriptional and/or epigenetic regulatory     networks that dictate the course of     the macrophage  immune response to infection and how deregulation of these networks could be of therapeutic benefit.

    Understanding macrophage polarization during Mycobacterium tuberculosis  (Mtb) infection:

    Macrophage polarization plays an important role in the containment of bacterial infections and in the resolution of inflammation. M1 macrophages typically elicit an    inflammatory response and contain infection, whereas M2 macrophages are involved in the resolution of inflammation. Using global transcriptome profiles of     macrophages infected with Mtb for different periods of time, in silico network analyses is being undertaken to identify central transcriptional regulators associated with     macrophage activation.

    Understanding mechanisms of cell division and stress response in mycobacteria. 

Publications:

RECENT PUBLICATIONS

 

 Kim, J.K., Kim, T.S., Basu, J.,  Jo, E.K. (2017) MicroRNA in innate immunity and autophagy during mycobacterial infection. Cell Microbiol. 1: doi: 10.1111/cmi.12687

 Kumar, R., Sahu, S.K., Kumar, M., Jana, K., Gupta, P., Gupta, U.D., Kundu, M.,   Basu J. (2016) MicroRNA 17-5p regulates autophagy in Mycobacterium tuberculosis-infected macrophages by targeting Mcl-1 and STAT3. Cell Microbiol. 18, 679–691.

 Kumar, M., Sahu, S.K., Kumar, R., Subuddhi, A., Maji, R.K., Jana, K., Gupta, P., Raffetseder, J., Lerm, M., Ghosh, Z., van Loo, G., Beyaert, G., Gupta, U.D., Kundu, M., Basu, J. (2015) MicroRNA let-7- modulates  the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-kappa B pathway. Cell Host Cell Host and Microbe, 17, 345-356.

 Halder, P., Kumar, R., Jana, K., Chakraborty, S., Ghosh, Z., Kundu, M.,  Basu, J. (2015)Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages. IUBMB Life 67, 726-736.

 Gupta, S., Banerjee, S.K., Chatterjee, A., Sharma, A.K., Kundu, M., Basu, J. (2015) The essential protein SepF of mycobacteria interacts with FtsZ and MurG to regulate cell growth and division. Microbiology, 161, 1627-1638.

 Sharma, A.K., Chatterjee, A., Gupta, S., Banerjee, R., Mandal, S., Mukhopadhyay, J., Basu, J., Kundu, M. (2015) MtrA, an essential response regulator of the MtrAB two component system regulates the transcription of resuscitation promoting factor B (RpfB) of Mycobacterium tuberculosis. Microbiology, 161, 1271-1281.

 Halder, P., Datta, C., Kumar, R., Sharma, A.K., Basu, J., Kundu, M. (2015) The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells.  Cell Microbiol. 17, 714-729.

 Basu, J., Shin, D.-M.  Jo, E.K. (2012) Mycobacterial signaling through toll-like receptors. Front . Cell. Infect. Microbiol., 2: 145.

 Kumar, R., Halder, P., Sahu, S.K., Kumar, M., Kumari, M., Jana, K., Ghosh, Z., Sharma, P., Kundu, M.  Basu, J (2012) Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cellular Microbiology, 141, 1620-1631.

 Natarajan, K., Kundu, M., Sharma, P.,  Basu J. (2011) Innate immune responses to M. tuberculosis infection. Tuberculosis (Edinb). 91, 427-431.

 Ghosh, S., Sureka, K., Ghosh, B., Bose, I., Basu, J.,  Kundu, M. (2011) Phenotypic heterogeneity in mycobacterial stringent response. BMC Systems Biology 5: 18.

 Dasgupta, A., Sureka, K., Mitra, D., Saha, B., Sanyal, S., Das,  A.K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M.,  Basu, J. (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS One 5 : e12225.

 Sureka, K., Hossain, T., Mukherjee, P., Chatterjee, P., Datta, P., Kundu, M., Basu, J. (2010) Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division.PLoS One. 5, e8590.

Barik, S., Sureka, K., Basu, J., and Kundu, M. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. (2009) Mol. Microbiol. 75,  592-606

Sureka, K., Sanyal, S., Basu, J. and Kundu, M. Polyphosphate kinse 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria. (2009) Mol. Microbiol. 74, 1187-1197

 Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S.,  Noguchi, T.,  Takeda, K.,  Ichijo, H., Thien,  C.B.F.,. Langdon, W.Y. and  and Basu, J. A tumor necrosis factor- and c-Cbl-dependent FLIPS degradation pathway and its role in Mycobacterium tuberculosis-induced macrophage apoptosis   (2009) Nature Immunol. 10, 918-925

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Recognition:

  • J.C. Bose National Fellowship, 2017
  • Fellow of the Indian National Science Academy, 2009
  • Fellow of the Indian Academy of Sciences, 2006
  • National Bioscience Award for Career Development (DBT), 2002
  • INSA Young Scientist Medal, 1989

Teaching:

Present:

Image Name Designation Department Campus Contact number Email
profile image Arijita Subuddhi SRF Chemistry Main 23031147 arijitas@gmail.com
profile image Debayan Majumder JRF Chemistry Main 23031145 debayan_majumder@yahoo.com
profile image Suruchi Lata SRF Chemistry Main 23031147 suruchilata@gmail.com

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