Biswanath Maity

Biswanath Maity
Professor

Previous appointments:

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Research interests:

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G-protein dependent/independent signaling in non-communicable diseases, particularly in heart and liver complications.

Contact:

Address: Biological Sciences
Unified Academic Campus
Bose Institute
EN-80, Sector V
Bidhan Nagar
Kolkata - 700 091, India
E-Mail: bmaity[at]jcbose.ac.in

Research:

Presently, India is going through rapid demographic-, environmental-, and lifestyle-related public health challenges, which has resulted in significant transitions in the magnitude and pattern of disease risk across the country particularly non-communicable diseases (NCD) including heart disease and chronic liver disease accounting >50% of deaths and representing a huge burden on Indian healthcare system. Aberrant activation of G protein-coupled receptors (GPCRs) and its modulators has now been implicated in these physiological aspects and identifying effective means to prevent or treat these disorders represents a critical barrier to the country’s progress.

The research program of Prof. Maity centers around how G-protein dependent/independent mechanism employ damage to a single tissue, resulting from exposure to cytotoxic stress, propagates across the organ and throughout the body by autocrine/paracrine mechanism due to the release of variety of inflammatory and fibrotic factors into the local microenvironment and, ultimately peripheral circulation. To prevent this pathogenic multi-organ crosstalk, a comprehensive understanding of both initiating events and mechanisms that maintain, amplify, and propagate these signals is required. We put effort  to dissect the role of G-protein signaling and its determinants in these physiological processes mostly heart/liver and identified a number of novel, druggable targets that have clinical utility in treatments or adjuvants across several NCDs.

Publications:

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As Corresponding Author:

 

1.    Kumar M, Sengar AS, Kumar P, Mukherjee S, Kumar D, Chatterjee S, Stewart A, Maity B*. FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms. Redox Biology 2025, 80, 103527 (Elsevier) [IF: 10.78]

 

2.    Raghul N, Lye A, Goswami B, Nayak S, Stewart A, Lo R, Maity B*, Das P [*equal]. Rationale Design of a Zn (II)-Coordinated, Cell Penetrating, and Functionalized Tetrapeptide Self-Assembly for Delivery of Chemotherapeutic Drugs to Folic Acid Receptor Expressing Cancer Cells. ACS Applied Bio Materials 2025 (Accepted on July 21, American Chemical Society Journal) [IF: 4.8]

 

3.    S Mallayasamy, Das K, Rana P, Saha A, Mandal D, Barik A, Stewart A, Maity B*, Das P* [*equal]. Liposomal encapsulation of chlorambucil with a terpyridine-based, glutathione-targeted optical probe facilitates cell entry and cancer cell death. ACS Applied Bio Materials 2024 (American Chemical Society Journal) [IF: 4.8]

 

4.    Panwar A, Lye A, Misub D, Upadhay A, Karankumar I, Devi PB, Pal M, Pal M, Maity B*, Roy M* [*equal]. Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis. Dalton Transactions, 2024, 53, 12119-12127 (RSC Journal) [IF: 3.5]

 

5.    Nayak S, Das K, Sivagnanam S, Baskara A, Stewart A, Kumar D, Maity B* & Das P*. [*equal]. Cystine-cored diphenylalanine appended peptide-based self-assembled fluorescent nanostructures direct redox responsive site-specific chemotherapeutic drug delivery. iScience 2024, 27,109523 (Cell Press) [IF: 6.107]

 

6.    Sengar AS, Kumar M, Rai C, Chakraborti S, Kumar D, Kumar P, Mukherjee S, Mondal K, Stewart A, Maity B*. RGS6 drives cardiomyocytes death following nucleolar stress by suppressing Nucleolin/miRNA-21. Journal of Translational Medicine 2024, 22, 204 (Springer-Nature).

 

7.    Basak M, Sengar AS, Das K, Mahata T, Kumar M, Kumar D, Biswas S, Kumar P, Das P, Stewart A, Maity B*. A RGS7-CaMKII complex drives myocyte-intrinsic and -extrinsic mechanisms of chemotherapy-induced cardiotoxicity. PNAS 2023 120, 1, e2213537120 (Direct submission) [IF: 11.2]

 

8.    Das K, Basak M, Mahata T, Biswas S, Kumar P, Mukerjee S, Stewart A, Maity B*. Cardiac RGS7 and RGS11 drives TGFβ1-dependent liver damage following chemotherapy exposure. The FASEB Journal 2023 37:e23064, (Wiley Journal) [IF: 5.834]

 

9.    Basak M, Das K, Mahata T, Kumar D, Nagar N, Poluri KM, Kumar P, Das P, Stewart A, Maity B*. RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation. Cellular and Molecular Life Sciences 2023 80, 9:255 (Springer) [IF: 9.2]

 

10.  Mallayasamy S, Das K, Guha S, Subramaniyam S, Das G, Saha A, Stewart A, Maity B* & Das P*. [*equal]. Liposomes Containing Zinc-Based Chemotherapeutic Drug Block Proliferation and Trigger Apoptosis in Breast Cancer Cells. ACS Applied Bio Materials 2023, 6, 12, 5310-5323, doi: 10.1021/acsabm.3c00587 (American Chemical Society Journal) [IF: 4.8]

 

11.  Sivagnanam S, Das K, Pan I, Stewart A, Barik A, Maity B* & Das P* [*equal]. Engineered triphenylphosphonium-based, mitochondrial-targeted liposomal drug delivery system facilitates cancer cell killing actions of chemotherapeutics. RSC Chemical Biology 2023 (DOI: 10.1039/D3CB00219E) (RSC Journal) [IF: 3.66]

 

12.  Subramaniyam S, Das K, Pan I, Barik A, Stewart A, Maity B* & Das P*. [*equal]. Functionalized fluorescent nanostructures generated from self-assembly of a cationic tripeptide direct cell selective chemotherapeutic drug delivery. ACS Applied Bio Materials 2023 6,2, 836-847 (American Chemical Society Journal) [IF: 4.8]

 

13.  Basak M, Das K, Mahata T, Sengar AS, Verma SK, Biswas S, Bhadra K, Stewart A, Maity B*. RGS7-ATF3-Tip60 complex promotes hepatic steatosis and fibrosis by directly inducing TNFα. Antioxidants & Redox Signaling 2023 38, 137-159 (Mary & Leibert) [IF: 8.40]

 

14.  Das K, Basak M, Mahata T, Kumar M, Kumar D, Biswas S, Chatterjee S, Kumar P, Moniruzzaman M, Saha NC, Mondal K, Das P, Stewart A, Maity B*. RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis. Redox Biology 2022 57, 102487 (Elsevier) [IF: 10.78]

 

15.  Sivagnanam S, Das K, Basak M, Mahata T, Stewart A, Maity B*, Das P*. [*equal]. Self-assembled dipeptide based fluorescent nanoparticles as a platform for developing cellular imaging probes and targeted drug delivery chaperones. Nanoscale Advances 2022 4, 1694-1706 (RSC Journal) [IF: 4.38]

 

16.  Sivagnanam S, Das K, Mahata T, Stewart A, Maity B*, Das P*. [*equal]. Generation of self-assembled structures composed of amphipathic, charged tripeptides for intracellular delivery of pro-apoptotic chemotherapeutics. Israel Journal of Chemistry 2022, e202200001, 1-15 [IF: 3.5]

 

17.  Chakraborti S, Stewart A, Maity B*. Impact of chemotherapeutic drugs towards oxidative stress and associated multiorgan physiological responses. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects 2022, pp 1-25 (Book chapter, Springer Nature)

 

18.  Mahata, T, Sengar AS, Basak M, Das K, Pramanick A, Verma SK, Singh PK, Biswas S, Sarkar S, Saha S, Chatterjee S, Stewart A, Maity B*. Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. Redox Biology 2021 46, 102105 (Elsevier) [IF: 11.799]

 

19.  Rana P, Das K, Pan I, Mandal D , Stewart A, Ghosh S*, Maity B*, Das P*. [*equal]. Fabrication of self-assembled nanostructures for intracellular drug delivery from diphenylalanine analogues with rigid or flexible chemical linkers. Nanoscale Advances 2021 3, 6176-6190 (RSC Journal) [IF: 4.38]

 

20.  Subramaniyam S, Basak M, Kumar A, Das K, Mahata T, Rana P,   Sengar AS, Ghosh S, Subramanian M, Stewart A, Maity B* & Das P*. [*equal]. Supramolecular structures generated via self-assembly of a cell penetrating tetrapeptide facilitate intracellular delivery of a pro-apoptotic chemotherapeutic drug. ACS Applied Bio Materials 2021 4:9, 6807-6820 (American Chemical Society Journal) [IF: 4.8]

 

21.  Pramanick A, Chakraborti S, Mahata T, Basak M, Das K, Verma S, Singh P, Biswas S, Sarkar S, Saha S, Agrawal V, Nath D, Chatterjee S, Stewart A, Maity B*. G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity. Redox Biology 2021 43, 101965 (Elsevier) [IF: 11.799]

 

22.  Chakraborti S, Pramanick A, Saha S, Sarkar S, Stewart A, Maity B*. Biphasic changes in TGF-beta 1 signaling drive NSAID-induced multi-organ damage. Free Radical Biology Medicine 2020 160, 125-140 (Elsevier). [IF: 7.376]

 

23.  Basak M, Mahata T, Chakraborti S, Kumar P, Das M, Bandyopdhyay SK, Stewart A, Saha S, Maity B*. Malabaricone C attenuates NSAID-induced gastric ulceration by reducing oxidative/nitrative stress and inflammation and promoting angiogenic auto-healing. Antioxidants & Redox Signaling 2020 32(11):766-784 (Mary Ann Liebert Inc). [IF: 8.40]

 

24.  Chakraborti S, Pramanick A, Saha S, Roy SS, Chaudhuri AR, Das M, Ghosh S, Stewart A, Maity B*. Atypical G protein β5 promotes cardiac oxidative stress, apoptosis, and fibrotic remodeling in response to multiple cancer chemotherapeutics. Cancer Research 2018 78(2) 528-541. (AACR Journal) [IF: 12.7]


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Recognition:

  • INSA Associate Fellow, 2024
  • Ramalingaswami Fellow, 2014
  • Ramanujan Fellow, 2014
  • AHA Posdoctoral Fellow, 2014

Teaching:

Part of Msc and PhD Course work of Bose Institute Program.


Students:

Image Name Designation Department Campus Contact number Email
profile image Arghya Acharyya Junior Research Fellow Biological Sciences Unified acharyayaarghya@gmail.com
profile image Pallobi Khatua Junior Research Fellow Biological Sciences Unified pallobikhatua3@gmail.com

Former:

!. Tarun Mahata (SRF)

2. Manish Kumar (SRF)

3. Chetna Rai (SRF)

4. Anyshree Lye (JRF)

5. Arghya Acharyya (JRF)

6. Pallabi Khatua (JRF)

7. Shreya Mallick (JRF)


Alumni:

1. Dr. Sreemoyee Chakraborti, Senior Scientist, Forensic Research Laboratory, WB

2. Dr. Arnab Pramanick, Entrepreneur 

3. Dr. Madhuri Basak, Postdoctoral Fellow, UCSF, USA

4. Dr. Kiran Das, Postdoctoral Fellow, UCLA, USA

5. Dr. Abhishek Singh Sengar, Postdoctoral Fellow, University of Pittsburg, USA

Group News: