Anirban Bhunia

Anirban Bhunia
Associate Professor

Research interests:

My lab is engaged in the systematic design of several peptides (which are considered as “nano-indicators”) and determine its three-dimensional structure using NMR spectroscopy in combination with molecular dynamics (MD) simulation to correlate its structure with  respective function such as antimicrobial activity, or antifreeze peptide or inhibitors of fibrillation.

Contact:

Address: Department of Biophysics
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: bhunia[at]jcbose.ac.in
Phone: +91-33-25693336

Research:

Publications:

2018

88. Nandi SK, Chakraborty A, Panda AK, Kar RK, Bhunia A, Biswas A* (2018)  Evidences for Zinc (II) and Copper (II) Ion Interactions with Mycobacterium leprae HSP18: Effect on its Structure and Chaperone Function.  Journal of Inorganic  Biochemistry (Just accepted). 

 

87. Pandit G1, Ilyas H1, Ghosh S, Bidkar A, Mohid SA, Bhunia A*, Satpati P*, Chatterjee S* (2018)  Insights into the Mechanism of Antimicrobial Activity of Seven-Residue Peptides. Journal of Medicinal Chemistry (Just accepted).  (1Both authors contributed equally)

 

86. Kar RK, Brender JR, Ghosh A, Bhunia A* (2018)  Non-productive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation.  Journal of Chemical Information and Modeling (Just accepted).

 

85. Bhattacharyya D, Kumar R, Mehra S, Ghosh A, Maji SK*, Bhunia A* (2018) Multitude NMR Studies of alpha-Synuclein Familial Mutants: Probing their Differential Aggregation Properties.  Chemical Communications 54, 3605-3608.

 

84. Ratha BN, Kim M, Sahoo B, Garai K, Lee D-K, Bhunia A* (2018) Insulin-Eukaryotic Model Membrane Interaction: Mechanistic Insight of Insulin Fibrillation and Membrane Disruption.  BBA - Biomembrane pii: S0005-2736(18)30049-X.

 

83. Ghosh A, Bhattacharyya D, Bhunia A* (2018) Structural Insights of a Self-assembling 9-Residue Peptide from the C-terminal tail of the SARS Corona Virus E-protein in DPC and SDS Micelles: A Combined High and Low Resolution Spectroscopic Study.  BBA - Biomembrane  1860, 335-346.  

 

82. Brender JR*, Krishnamoorthy J, Ghosh A, Bhunia A (2018) Binding Moiety Mapping by Saturation Transfer Difference NMR.  Rational Drug Design: Methods and Protocols (Methods in Molecular Biology) by Springer Nature, Edited by T. Mavromoustakos and T. Kellici  1824, 49-65.

 

2017

81. Singh S, Datta A,  Bruno B, Davoudi M, Schmidtchen A, Bhunia A*, Malmsten M* (2017) Conformational aspects of high content packing of antimicrobial peptides in polymer microgels.  ACS Applied Material and Interface 9, 40094-40106.

 

80. Loffredo MR#, Ghosh A#, Harmouche N, Casciaro B, Luca V, Bortolotti A, Cappiello, F, Stella L, Bhunia A, Bechinger B, Mangoni ML* (2017) Membrane Perturbing Activities and Structural Properties of the Frog-skin Derived Esculentin-1a(1-21)NH2 and its Diastereomer Esc(1-21)-1c: Correlation With Their Antipseudomonal and Cytotoxic Activity.  BBA - Biomembrane 1859(12), 2327-2339   (#Both authors contributed equally)

 

79. Chowdhury R#, Ilyas H#, Ghosh A, Ali H, Ghorai A, Midya A, Jana NR, Das SS,* Bhunia A* (2017) Multivalent Gold nanoparticle - Peptide Conjugates for Targeting Intracellular Bacterial Infection.  Nanoscale   9(37), 14074-14093.    (#Both authors contributed equally)

 

78. Bera S, Bhunia A* (2017) Cell Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implications for Pathogenesis and Therapeutic Treatment of Neurodegenerative Disease.  Methods and Protocols (Methods in Molecular Biology) by Springer Nature, Edited by Tatiana Barrichello and Wolfgang Walz  (Invited Book Chapter)

 

77. Mukherjee S, Kar RK, Nanga RPR, Mroue KH,  Ramamoorthy A,* Bhunia A* (2017) Accelerated Molecular Dynamics Simulation Analysis of MSI-594 in Lipid Bilayer.  Phys Chem Chem Phys.  19, 19289-19299. 

 

76. Zhang R, Wu L, Eckert T, Roderfeld M, Rojas-Macias-M M, Lütteke T, Krylov VB, Argunov DA, Datta A, Markart P, Günther A, Norden B, Schauer R, Bhunia A,  Mushira AE, Billeter M, Scheidig AJ, Nifantiev NE, Siebert HC (2017) Lysozyme's Lectin-like Characteristics Facilitates its Immune Defense Function. QRB Discovery 50, e9.

 

75. Jana M, Ghosh A, Santra A, Kar RK, Misra AK,* Bhunia A* (2017) Synthesis of Novel Muramic Acid Derivatives and Their Interaction with Lysozyme: Action of Lysozyme Revisited. J Colloid Int Sci 498, 395-404.

 

74. Datta A, Jaiswal N, Ilyas H, Debnath S, Biswas K, Kumar D,* Bhunia A* (2017) Structure and Dynamic Insights into a Glycine-Mediated Short Analogue of a Designed Peptide in Lipopolysaccharide Micelles: Correlation Between Compact Structure and Anti-Endotoxin Activity. Biochemistry 56, 1348 - 1362.

 

73. Singh S*#, Datta A#, Schmidtchen A, Bhunia A, Malmsten M (2017) Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects. Sci. Rep. (Nature Publishing Group) 7, 212.    (#Both authors contributed equally)

 

72. Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee Y-H, Rosa CL, Lim MH, Ramamoorthy A* (2017) Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid beta. J. Biol. Chem.  292, 4638 - 4650. 

 

71. Ilyas H, Datta A, Bhunia A* (2017) An Approach Towards Structure Based Antimicrobial Peptide Design For Use In Development of Transgenic Plants: A Strategy For Plant Disease Management. Curr. Med. Chem.  24, 1350 - 1364.   (Invited review article)

 

70. Ghosh A, Pradhan N, Bera S, Datta A, Krishnamoorthy J, Jana NR, Bhunia A* (2017) Inhibition and Degradation of Amyloid Beta (Aβ40) Fibrillation by Designed Small Peptide: A Combined Spectroscopy, Microscopy and Cell Toxicity Study. ACS Chem Neuroscience  8, 718-722.

 

2016

 

69. Manila RS, Ta A, Sinha R, Theeya N, Ghosh A, Tasneem M, Bhunia A,  Koley H, Das S* (2016) Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators.  Sci. Rep. (Nature Publishing Group)  6, 39454.

 

68. Ratha BN, Ghosh A, Brender JR, Gayen N, Ilyas H, Neeraja C, Das KP, Mandal AK, Bhunia A* (2016) Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: Mechanistic Details Studied by Spectroscopy in Combination with Microscopy.  J. Biol. Chem.  291, 23545-23556.

 

67. Datta A, Yadav Y, Ghosh A, Choi J, Bhattacharyya D, Kar RK, Ilyas H, Dutta A, An E, Mukhopadhyay J, Lee DK, Sanyal K, Ramamoorthy A, Bhunia A* (2016) Mode of Action of A Designed Antimicrobial Peptide : High Efficiency in Killing the Human Fungal Pathogen Cryptococcus neoformans. Biophysical Journal  111, 1724-1737. This article has been selected as "Featured article" as well as "slider" by the journal !!!!        

 

66. Pal I, Brahmhatri VP, Bera S, Bhattacharyya D, Quirishi Y, Bhunia A*, Atreya HS* (2016) Enhanced Stability And Activity of an Antimicrobial Peptide in Conjugation With Silver Nanoparticle. J. Colloid Interface Sci., 483, 385-393.

 

65. Bera S, Kar RK, Mondal S, Pahan K, Bhunia A* (2016) Structural Elucidation of Cell-Penetrating Penetratin Peptide in Model Membranes at Atomic Level : Probing Hydrophobic Interactions in the Blood-Brain-Barrier. Biochemistry  55, 4982-4996.

 

64. Roy A, Dutta A, Roy D, Ganguly P, Ghosh R, Kar RK, Bhunia A, Mukhopadhyay J, Chaudhuri S* (2016) Deciphering the role of the AT-rich interaction domain and the HMG-box domain of ARID-HMG proteins of Arabidopsis thaliana. Plant Mol. Biol.  Just accepted.

 

63. Bera S, Korshavn KJ, Kar RK, Lim MH, Ramamoorthy A, Bhunia A* (2016) Biophysical Insights into the Membrane Interaction of the Core Amyloid Forming Ab40 Fragment K16-K28 and its Role in the Pathogenesis of Alzheimer's Disease. Phys Chem Chem Phys.  18, 16890-901.

 

62. Mitra P, Pal U, Maiti NC, Ghosh A, Bhunia A, Basu S* (2016) Identification of Modes of Interactions Between 9-Aminoacridine Hydrochloride Hydrate and Serum Proteins by Low and High Resolution Spectroscopy and Molecular Modeling. RSC Adv.  6, 53454 - 68.

 

61. Bhaumik I, Kar RK, Bhunia A, Misra A* (2016) Expedient Synthesis of Pentasaccharide Repeating Unit of the O-antigen of E.coli 086 and Its Conformational Analysis.  Glycoconj. J.  Just Accepted.

 

60. Datta A, Bhattacharyya D, Singh S, Ghosh A, Schmidtchen A, Malmsten M*, Bhunia A* (2016) Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control.  J. Biol. Chem.   291, 13301 - 17.

 

59. Kar RK, Gazova Z, Bednarikova Z, Mroue KH, Ghosh A, Zhang R, Ulicna K, Siebert HC, Nifantiev NE, Bhunia A* (2016) Evidence for Inhibition of Lysozyme Amyloid Fibrillization by Peptide Fragments from Human Lysozyme: A Combined Spectroscopy, Microscopy and Docking Study.  Biomacromolecules   17, 1998 -2009 .

 

58. Roy P, Dhara D, Parida PK, Kar RK, Bhunia A, Jana K, Sinha-Babu SP, Misra A* (2016) C-Cinnamoyl glycosides as a new class of anti-filarial agents.  Eur. J. Med. Chem.  114, 308-17.

 

57. Kar RK, Mroue KH, Kumar D, Tejo BA, Bhunia A* (2016) Structure and Dynamics of Antifreeze Protein - Model Membrane Interactions: A Combined Spectroscopic and Molecular Dynamics Study.  J. Phys. Chem. B  120, 902-914.

 

56. Ghosh A, Bera S, Shai Y, Mangoni, ML, Bhunia A* (2016) NMR Structure and Binding of Esculentin-1a (121)NH2 and Its Diastereomer To Lipopolysaccharide: Correlation With Biological Functions. BBA - Biomembrane  1858, 800-812.

 

55. Korshavn KJ, Bhunia A, Lim MH, Ramamoorthy A* (2016) Ab40 Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Bilayers Prior to Amyloid Formation. ChemComm. 52, 882-5. Selected for Cover page !!!!

 

54. Pithadia AS, Bhunia A, Sribalan R, Padroni V, Fierce CA, Ramamoorthy A* (2016) Influence of a Curcumin Derivative on hIAPP aggregation in the Absence and Presence of Lipid Membrane. ChemComm. 52, 942-5. This paper has been recommended by Faculty 1000 Prime !!!!

 

53. Mangoni ML*, Bhunia A*, (2016) Editorial: Antimicrobial Peptides in Medicinal Chemistry: Advances and Applications. Curr. Top. Med. Chem. 16, 2-3.

 

52. Sharma S, Sahoo N, Bhunia A*, (2016) Antimicrobial Peptides and their Pore/Ion Channel Properties in Neutralization of Pathogenic Microbes.  Curr. Top. Med. Chem., 16, 42-53.

 

51. Datta A, Kundu P, Bhunia A* (2016) Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding. J. Colloid Interface Sci., 461, 335-345.

 

 

 

2015

50. Korshavn K, Jang M, Kwak YJ, Kochi A, Vertuani S, Bhunia A, Manfredini S, Ramamoorthy A*, Lim MH* (2015) Reactivity of Metal-Free and Metal-Associated Amyloid-beta with Glycosylated Polyphenols and Their Esterified Derivatives. Nature Sci. Rep.  5, 17842.

 

49. Kar RK, Bhunia A* (2015) Biophysical and Biochemical Aspects of Antifreeze Proteins: Using Computational Tools to Extract Atomistic Information. Progress Biophys. Mol. Biol., 119, 194-201.

 

48. Kar RK, Bhunia A* (2015) Will It Be Beneficial to Simulate The Antifreeze Proteins at Ice Freezing Condition or at Lower Temperature? J. Phys. Chem B, 119, 11485-95.

 

47. Ghosh A#, Ratha BN#, Gayen N, Mroue KH, Kar RK, Mandal AK*, Bhunia A* (2015) Biophysical Characterization of Essential Phosphorylation at the Flexible C-terminal Region of C-Raf with 14-3-3ζ Protein. PLOS One, 10 (8), e0135976.    This paper has been recommended by Faculty 1000 Prime !!!!  (#Both authors contributed equally)

 

46. Datta A, Ghosh A, Airoldi C, Sperandeo P, Mroue KH, Barbero JJ, Kundu P, Ramamoorthy A, Bhunia A* (2015) Antimicrobial peptides: Insight into Membrane Permeabilization, Lipopolysaccharide Fragments and Application in Plant Disease Control. Nature Sci. Rep., 5, 11951.

 

45. Gupta S, Chit JC-Y, Feng C, Bhunia A, Tan S-M, Bhattacharjya S* (2015) An Alternative phosphorylation switch in Integrin b2 (CD18) tail for DOK1 binding. Nature Sci. Rep., 5, 11630.

 

44. Bera S, Ghosh A, Sharma S, Debnath T, Giri B, Bhunia A* (2015) Probing the role of Proline in the Antimicrobial activity and lipopolysaccharide binding of Indolicidin. J Colloid Interface Sci., 452, 148-159.

 

43. Ghosh A, Pithadi A, Bhat J, Bera S, Midya A, Fierke C, Ramamoorthy A, Bhunia A* (2015) Self-assembly of a 9-residue amyloid-forming peptide fragment of SARS Corona Virus E-protein: Mechanism of self aggregation and amyloid inhibition of hIAPP. Biochemistry, 54, 2249 -2261

 

42. Lee DK, Bhunia A, Kotler SA, Ramamoorthy A* (2015) Antimicrobial peptides and inhibition by cholesterol: A solid-state Nuclear Magnetic Resonance study. Biochemistry, 54, 1897-907.

 

41.  Nandi SK, Chakraborty A, Panda AK, Ray SS, Kar RK, Bhunia A, Biswas A* (2015) Interaction of ATP with a small heat shock protein from Mycobacterium leprae: Effect on its structure and function.  PLOS Negl. Trop. Diseas., 9, e0003661.

 

40. Sudheendra US, Dhople V, Datta A, Kar RK, Shelburne CE, Bhunia A*, Ramamoorthy A*  (2014) Membrane Disruptive Antimicrobial Activities of Human beta defensin-3 Analogs. Eur. J. Med. Chem., 91, 91-99.

 

2014

39. DiMauro MA, Nandi SK, Raghavan CT, Kar RK, Wang B, Bhunia A, Nagaraj RH*, Biswas A* (2014) Acetylation of Gly1 and Lys2 promotes aggregation of human gD-crystallin. Biochemistry, 53(46), 7269-82.

 

38. Ghosh T, Kar RK, Bhunia A, Misra A* (2014) Synthesis of the pentasaccharide repeating unit of the O-antigen of E.coli 0175 using one-pot glycosylation and its conformational analysis. Tetrahedron, 53(46), 7269-82.

 

37. Jana M, Kar RK, Bhunia A, Misra A* (2014) Synthesis of the tetrasaccharide repeating unit of the O-antigen of the Escherichia coli O69 strain and its conformational analysis.. RSC Adv., 4, 079-84.

 

36. Ghosh A, Kar RK, Krishnamoorthy J, Chatterjee S*, Bhunia A* (2014) Double GC:GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High-Resolution NMR Study. ChemMedChem., 9(9), 2052-58.  (invited paper).

 

35. Ghosh A, Kar RK, Jana J, Saha A, Jana B, Krishnamoorthy J, Kumar D, Ghosh S*, Chatterjee S*, Bhunia A* (2014) Indolicidin Targets Duplex DNA: Structural and Mechanistic Insights Employing Combination of Spectroscopy and Microscopy. ChemMedChem. 9(9), 2059-64   (invited paper).

 

34. Dhara D, Kar RK, Bhunia A*, Misra AK*  (2014) Convergent Synthesis and Conformational Analysis of the Hexasaccharide Repeating Unit of the O-Antigen of Shigella flexneri Serotype 1D. Eur. J. Org. Chem.  42014, 4577-84.,

 

33. Ravichandran Y, Krishnamoorthy J, Ramamoorthy A*, Bhunia A* (2014) Potent gamma-secretase inhibitors/modulators interacts with Amyloid-beta fibrils but do not inhibit fibrillation: A high resolution NMR study. Biochem. Biophys. Res. Comm., 447(4), 590 -5.

 

32. Ghosh A, Datta A, Jana J, Kar RK, Chatterjee C, Chatterjee S*, Bhunia A* (2014) Sequence context induced antimicrobial activity: Insight to Lipopolysaccharide permeabilization. Mol. Biosyst., 10(6), 1596-612.

 

31. Santra A, Si A, Kar RK, Bhunia A*, Mishra AK*  (2014) Linear synthesis and conformational analysis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O13. Carbohydr. Res., 391, 9-15.   

 

 

 

 

2013

30. Saravanan R, Joshi M, Mohanram H, Bhunia A, Bhattacharjya S (2013) NMR structure of temporin-1 ta in lipopolysaccharide micelles: mechanistic insight into inactivation by outer membrane. PLOS One, 8(9), e72718.

 

29.  Banejee V, Kar RK, Datta A, Parthasarathi K, Chatterjee S, Das KP*, Bhunia A* (2013) Use of Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy. PLOS One, 8(8), e72318.

 

28.  Jana J, Kar RK, Ghosh A, Biswas A, Ghosh S, Bhunia A*, Chatterjee S* (2013) Human Cathelicidin Peptide LL37 Bind Telomeric G-Quadruplex. Mol. Biosys.  9(7):1833-6.

 

27.  Kar RK, Suryadevara P, Jana J, Bhunia A*, Chatterjee S* (2013) Novel G-quadruple Stabilizing Agents: In-silico Approach and Dynamics. J. Biomol. Str. Dynam. 31: 1497-518.

 

2012

26.  Shah SHH, Kar RK, Asmawi AA, Rahman MBA, Murad AMA, Mahadi NM, Basri M, Rahman RNZAR, Salleh AB, Chatterjee S*, Tejo BA*, Bhunia A* (2012) Solution Structures, Dynamics, and Ice Growth Inhibitory Activityof Peptide Fragments Derived from an Antarctic Yeast Protein. PLOS One, 7(11), e49788.            

 

25. Mohanram H, Nip A, Domadia PN, Bhunia A, Bhattacharjya S. (2012) NMR structure, localization, and vesicle fusion of chikungunya virus fusion Peptide. Biochemistry, 51(40), 7863-72.

 

24. Bhunia A, Mohanram H, and Bhattacharjya S. (2012) Structural Determinants of the Specificity of a Membrane Binding Domain of the Scaffold Protein Ste5 of Budding Yeast: Implications in Signaling by the Scaffold Protein in MAPK Pathway. Biochim. Biophys. Acta, 1818(5), 1250-60.

 

23. Bhunia A*, Bhattacharjya S, Chatterjee, S. (2012) Applications of Saturation Transfer Difference (STD) NMR in Biological Systems. Drug Discov. Today, 17(9-10), 505-13.

 

2011

22. Bhunia A, Saravanan R, Mohanram H, Mangoni ML, Bhattacharjya S. (2011) NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide Micelles: mechanistic insights into outer membrane permeabilization and synergistic activity. J. Biol Chem., 286(7), 24394-406.

 

2010

21. Domadia PN, Bhunia A, Ramamoorthy A, Bhattacharjya S. (2010) Structure, Interactions, and Antibacterial activities of MSI-594 derived mutant peptie MSI-594F5A in Lipolysaccharide Micelles: Role of the Helical Hairpin Conformation in Outer-Membrane Permeabilization. J. Am. Chem. Soc., 132 (51), 18417-28.

 

20. Bhunia A, Vivekanandan S, Eckert T, Burg-Roderfeld M, Wechselberger R, Romanuka J, Bäle D, Kornilov AV, von der Leith C-W, Barbero JJ, Nifantiev N, Schachner M, Sewald N, Lü T, Gabius, H-J, Siebert H-C. (2010) Why the structurally different cyclic peptides can be glycomemtics of HNK-1? J. Am. Chem. Soc, 132, 96-105.

 

19. Bhunia A, Bhattacharjya S. (2010) Mapping Residue Specific Contacts of Polymyxin B with Lipopolysaccharide by Saturation Transfer Difference (STD) NMR: Insights into Outer-membrane Disruption and Endotoxin Neutralization. Biopolymers, 96, 273-287.

 

18. Bhunia A, Domadia PN, Torres J, Ramamoorthy A, Bhattacharjya S. (2010) NMR Structure of Pardaxin, a Pore-Forming Antimicrobial Peptide, in Lipopolysaccharide Micelles: Mechanism of Outer membrane Permeabilization. J. Biol. Chem., 285(6), 3883-95.

 

17. Domadia PN, Li YF, Bhunia A, Mohanram H, Tan SM, Bhattacharjya S. (2010) Functional and structural characterization of the talin F0F1 domain. Biochem. Biophys. Res. Commun. 391(1), 159-65.

 

16. Rathi S, Bhunia A, Bhattacharjya S. (2010) Role of the Central Hinge Region in the Structure and Activity of Melittin: Designing Non-toxic Antisepsis/Antimicrobial Agents. Biochim. Biophys. Acta, 1798(2), 128-139. (Invited Paper).

 

2009

15. Bhunia A, Mohanram H, Domadia PN, Bhattacharjya S. (2009) Designed b-Boomerang Antiendotoxic and Antimicrobial Peptides: Structures and Activities in Lipopolysaccharide. J. Biol. Chem., 284(33), 21991-2004. (Selected for “Papers of the Week”) (http://www.jbc.org/content/284/33/21991/suppl/DC1/-/2).

 

14. Bhunia A, Ramamoorthy A, Bhattacharjya S. (2009), Helical Hairpin Structure of a Potent Antimicrobial Peptide MSI-594 in Lipopolysaccharide Micelles by NMR. Chemistry: A European Journal, 15 (9), 2036-40.

 

13. Bhunia A, Tang XY, Mohanram H, Tan SM, Bhattacharjya S. (2009), NMR Solution Conformations and Interactions of Integrin aLb2 Cytoplasmic Tails. J. Biol.Chem., 284(6), 3873-84.

 

12. Bhunia A, Mohanram H, Bhattacharjya S. (2009), Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear overhauser effect spectroscopy. Biopolymers, 92(1), 9-22. (Selected for cover page).

 

11. Bhunia A, Domadia PN, Mohanram H, Bhattacharjya S. (2009), NMR structural studies of the Ste11 SAM domain in the dodecyl phosphocholine micelle. Proteins: Structure, Function and Bioinformatics, 74(2), 328-43.

 

2008

10. Bhunia A, Schwardt O, Gäje H, Gao GP, Kelm S, Benie AJ, Hricovini M, Peters T, Ernst B. (2008), Consistent bioactive conformation of the Neu5Ac-a-(2®3)Gal epitope upon lectin binding. ChemBioChem, 9(18), 2941-5.

 

9. Bhunia A, Chua GL, Domadia PN, Warshakoon H, Cromer JR, David SA, Bhattacharjya S. (2008), Interactions of a designed peptide with lipopolysaccharide: Bound conformation and anti-endotoxic activity. Biochem. Biophys. Res. Commun., 369, 853-7.

 

8. Domadia PN, Bhunia A, Sivaraman J, Swarup S, Dasgupta D. (2008), Berberine targets assembly of Escherichia coli cell division protein FtsZ. Biochemistry, 47, 3225-34.

 

7. Bhunia A, Domadia PN, Xu X, Gingras R, Ni F, Bhattacharjya S. (2008), Equilibrium unfolding of the dimeric SAM domain of MAPKKK Ste11 from the budding yeast: role of the interfacial residues in structural stability and binding. Biochemistry, 47, 651-9.

 

2007

6. Domadia PN, Bhunia A, Swarup S, Sivaraman J, Dasgupta D. (2007), Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde. Biochem. Pharmacol., 74, 831-40.

 

5. Bhunia A, Domadia PN, Bhattacharjya S. (2007), Structural and thermodynamic analyses of the interaction between melittin and lipopolysaccharide. Biochim. Biophys. Acta, 1768, 3282-91.

 

4. Bhattacharjya S, Domadia PN, Bhunia A, Malladi S, David SA. (2007), High-resolution solution structure of a designed peptide bound to lipopolysaccharide: transferred nuclear Overhauser effects, micelle selectivity, and anti-endotoxic activity. Biochemistry, 46, 5864-74.

      

     

                                                    2006 and before

3. Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK. (2006), Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. J. Mol. Biol., 364, 536-49. 

2. Bhunia A, Jayalakshmi V, Benie AJ, Schuster O, Kelm S, Rama Krishna N, Peters T. (2004), Saturation transfer difference NMR and computational modeling of a sialoadhesin-sialyl lactose complex. Carbohydr. Res., 339, 259-67 (Most cited paper award from Elsevier publishers).

1. Bhunia A, Durani S, Wangikar PP. (2001), Horseradish peroxidase catalyzed degradation of industrially important dyes. Biotechnol. Bioeng., 72, 562-7.


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Recognition:

  • NMRS-Prof. S. Subramanian's 60th Birthday lecture award for exceptional contribution to the field of Magnetic Resonance and its Applications., 2017
  • DST Young Scientist FAST Track grant, Govt. of India., 2012
  • PhD scholarship from “Graduiertenkolleg 464”, Deutsche Forschungsgemeinschaft (German Research Foundation), Germany., 2001
  • M.Sc (Biotechnology) scholarship from Department of Biotechnology (DBT), Government of India., 1999
  • Gold Medal for the first rank in B.Sc (Chemistry Hons.)., 1997

Teaching:

Biomolecular NMR spectroscopy course for MSc -PhD / PhD students

Students:

Image Name Designation Department Campus Contact number Email
profile image Abdul Mohid Junior Research Fellow Biophysics Centenary 25693336 skabdulmohid1992
profile image Dibakar Sarkar Junior Research Fellow Biophysics Centenary 25693336 dibakar
profile image Dipita Bhattacharyya Junior Research Fellow Biophysics Centenary 25693336
profile image Humaira Ilyas Senior Research Fellow Biophysics Centenary 25693336 humaira2204
profile image Karishma Biswas Junior Research Fellow Biophysics Centenary 25693336
profile image Nabarupa Chowdhury Junior Research Fellow Biophysics Centenary 25693321
profile image Ranit Pariary Junior Research Fellow Biophysics Centenary 25693218
profile image Shruti Mukherjee Junior Research Fellow Biophysics Centenary 25693336 shruti5581

Former:

Current Graduate Students


Bhisma N. Ratha

M.S. (Pharm.) in Biotechnology (NIPER-Hajipur)

2014 - Till Date)

UGC Ad-hoc (Senior Research Fellow)

Research area - Chaperone peptide and Structural insights of Myelin associated glycoprotein and its association with ganglosides.

Contact - bhisma.n.ratha@gmail.com

 

Swapna Bera

M.Sc. in Life Sciences (Biophysical Chemistry) (Bose Institute)

2014 - Till Date)

UGC Ad-hoc (Junior Research Fellow)

Research area - Structural insights of amyloid beta peptides in membrane

Contact - swapna.bera317@gmail.com

 

Humaira Ilyas

M.Sc. in Life Sciences (Molecular & Cellular Biology) (Bose Institute)

(2015 - Till Date)

Institute Fellow  (Junior Research Fellow)

Research area - Transgenic plant using de novo designed AMPs and studying their effect on inflammatory and cancer pathway.

Contact - humairailyas2204@gmail.com

 

Sk. Abdul Mohid

M.Sc. in Life Sciences (Biophysical Chemistry) (Bose Institute)

(2016 - Till Date)

Institute Fellow (Junior Research Fellow)

Research Area - Biophysical study of Antimicrobial Peptide

Contact - skabdulmohid1992@gmail.com

 

Dipita Bhattacharyya

M.Sc. in Zoology (Calcutta University)

(2015 - Till Date)

UGC Ad-hoc (Junior Research Fellow)

Research area - Biophysical studies of membrane - Alpha-Synuclein interaction

Contact - dipita15791@gmail.com

 

Shruti Mukherjee

M.Sc. in Zoology (Calcutta University)

(2016 - Till Date)

UGC Ad-hoc (Junior Research Fellow)

Research area - Biophysical studies of Antimicrobial peptide

Contact - diya.9290@gmail.com

 

Dibakar Sarkar

M.Sc. in Biophysics (Kalyani University)

(2017 - Till Date)

DST Inspire Fellow

Research area - Kinetics of Amyloid proteins

Contact - dibakar647@gmail.com

 

Ranit Pariary

M.Sc. in Chemistry (IIT Kharagpur)

(2017 - Till Date)

UGC Ad-hoc (Junior Research Fellow)

Research area - NMR and Amyloid proteins

Contact - ranitpariary@gmail.com

 

Karishma Biswas

M.Sc. in Biotechnology (Calcutta University)

(2017 - Till Date)

Junior Research Fellow from Indo-Sweden bilateral collaboration

Research area - Antimicrobial Peptides on crop disease

Contact - karishmabiswas93@gmail.com

 

Nabarupa Chowdhury

M.Sc. in Microbiology (West Bengal State University)

(2017 - Till Date)

Junior Research Fellow from CSIR funded project

Research area - Crosstalk between Amyloid proteins

Contact - nabarupachowdhury7@gmail.com


Group News:

Congratulations Dr Bhunia for joining the Editorial Board member of "Journal of Colloid and Interface Science (IF=5.1)"

Congratulations Humaira, Mohid and others for publication in "Journal of Medicinal Chemistry"

Congratulations Dipita for receiving "EMBO travel"  grant award to attend EMBO NMR Workshop on "Challenges for Magnetic Resonance in Life Sciences".

Congratulations Bhisma for receiving "DBT-CTEP" travel grant to attend FEBS Congress 2017. 

Congratulations Dr Bhunia for receiving "NMRS-Prof. S. Subramanian's 60th Birthday lecture award"  (in recognition of exceptional contribution to the field of Magnetic Resonance and its Applications).

Our research has been highlighted in "India times" newspaper (Click for details