Assistant Professor, Biochemistry
PhD: Department of Biochemistry, University of Calcutta, 2008
1. Max Planck Postdoctoral Fellow at Max Planck Institute for Terrestrial Microbiology, Marburg, Germany (2008-2012).
2. Research Associate at Department of Biochemistry, University of Calcutta (2012-2013).
The main focus of my research group is to understand the eco-physiology of archaea, the third domain of life. We use different experimental tools to get an insight into the unique biological machinery in archaea. Besides, we are actively engaged in structural and functional genomics analysis of different microorganisms.
Department of Biochemistry
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
Archaeal stress response:
Study of archaea, the third domain of life, can provide interesting insights into the evolutionary history of different cellular machineries and mechanisms across all life forms. One such mechanism of our concern is that of protein translocation across biological membranes in archaea. Our present focus is on the structural and functional analyses of molecules that are central to the archaeal secretion process under different limiting conditions. Since archaea can sustain such extreme limiting conditions, withstanding different kinds of stresses, we also aim to get a thorough idea about the effect of different types of stressors on archaeal cells at the transcriptomic and proteomic level. We want to study the fate of stress-related proteins under conditions of stress, which includes identification, characterization, and analysis of the mode of regulation of stress-related proteins and their targets. Therefore, the current research in our lab is concerned with understanding the effect of heat stress on archaea in regard with different molecular chaperones. In addition, our recent venture is to study the components of archaeal defense mechanism, that is, the CRISPR-Cas system and their mode of action in conferring resistance to biotic stress, such as foreign genetic elements.
Structural and Functional Genomics of Microbes:
Another area of interest of our lab is to understand the diversity, distribution, and interaction of microbes with the environment. Our model system of study, the Sundarbans are the largest single stretch of the deltaic halophytic mangrove ecosystem in the world and has been recognized as a world heritage site by UNESCO. Till date, only little is known about the microbial diversity, distribution, and function within this mangrove sediment. Hence, our group is interested in understanding the microbial diversity, with special emphasis on the archaea of this ecologically important region. In parallel to this, our group is also involved in studying plant-microbe interactions at the genomic and functional levels.
1. Bhattacharyya C, Bakshi U, Mallick I, Mukherji S, Bera B & Ghosh A. Genome-guided insights into the plant growth promotion capabilities of the physiologically versatile Bacillus aryabhattai strain AB211. Frontiers in Microbiology, 8, 411 (2017)
2. Gupta S, Roy M & Ghosh A. The Archaeal Signal Recognition Particle: Present Understanding and Future Perspective. Current Microbiology, 74, 284-297 (2017)
3. Mahanty T, Bhattacharjee S, Goswami M, Bhattacharyya P, Das B, Ghosh A & Tribedi, P. Biofertilizers: a potential approach for sustainable agriculture development. Environ Sci Pol Res Int, 24, 3315-3335 (2016)
4. Basak P, Pramanik A, Sengupta S, Nag S, Bhattacharyya A, Roy D, Pattanayak R, Ghosh A, Chattopadhyay D & Bhattacharyya M. Bacterial diversity assessment of pristine mangrove microbial community from Dhulibhashani, Sundarbans using 16S rRNA gene tag sequencing. Genomics Data, 7, 76-78 (2016)
5. Chaudhury P, Neiner T, D'Imprima E, Banerjee A, Reindl S, Ghosh A, Arvai AS, Mills DJ, van der Does C, Tainer JA, Vonck J & Albers SV. The nucleotide- dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor. Mol Microbiol, 99, 674-685 (2016)
6. Saha S, Jana S, Gupta S, Ghosh A & Nayek HP. Syntheses, structures and biological activities of square planar Ni(II), Cu(II) complexes. Polyhedron, 107, 183-189 (2016)
7. Basak P, Majumder NS, Nag S, Bhattacharyya A, Roy D, Chakraborty A, SenGupta S, Roy A, Mukherjee A, Pattanayak R, Ghosh A, Chattopadhyay D & Bhattacharyya, M. Spatiotemporal Analysis of Bacterial Diversity in Sediments of Sundarbans Using Parallel 16S rRNA Gene Tag Sequencing. Microb Ecol, 69, 500-511 (2015)
8. Bera A, Ghosh A, Mukhopadhyay A, Chattopadhyay D & Chakrabarti K. Improvement of degummed ramie fiber properties upon treatment with cellulase secreting immobilized A. larrymoorei A1. Bioproc Biosyst Eng, 38, 341-351 (2015)
9. Bhattacharyya A, Majumder NS, Basak P, Mukherji S, Roy D, Nag S, Haldar A, Chattopadhyay D, Mitra S, Bhattacharyya M & Ghosh, A. Diversity and Distribution of Archaea in the Mangrove Sediment of Sundarbans. Archaea, 968582 (2015)
10. Chakraborty A, Bera A, Mukherjee A, Basak P, Khan I, Mondal A, Roy A, Bhattacharyya A, SenGupta S, Roy D, Nag S, Ghosh A, Chattopadhyay D & Bhattacharyya M. Changing bacterial profile of Sundarbans, the world heritage mangrove: Impact of anthropogenic interventions. World J Microb Biotechnol, 31, 593-610 (2015)
11. Mahato M, Dey D, Pal S, Saha S, Ghosh A, Harms K & Nayek HP. Syntheses, structures, optical properties and biological activities of bimetallic complexes. RSC Advances, 4, 64725-64730 (2015)
12. Sengupta S, Pramanik A, Ghosh A & Bhattacharyya M. Antimicrobial activities of actinomycetes isolated from unexplored regions of Sundarbans mangrove ecosystem. BMC Microbiol, 15, 170 (2015)
13. Henche AL, van Wolferen M, Ghosh A & Albers SV. Dissection of key determinants of cleavage activity in signal peptidase III (SPaseIII) PibD. Extremophiles, 18, 905-913 (2014)
14. Wagner M, Wagner A, Ma X, Kort JC, Ghosh A, Rauch B, Siebers B & Albers SV. Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius. Appl Env Microbiol, 80, 1072-1081 (2014)
15. Reindl S, Ghosh A, Williams, GJ, Lassak, K, Neiner, T, Henche AL, Albers SV & Tainer JA Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics. Molecular Cell, 49, 1069-1082 (2013)
16. Banerjee A, Ghosh A, Mills DJ, Kahnt J, Vonck J & Albers, S.V. FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI. J Biol Chem, 287, 43322-43330 (2012)
17. Henche AL, Ghosh A, Yu X, Jeske T, Egelman E & Albers SV. Structure and function of the adhesive type IV pilus of Sulfolobus acidocaldarius. Environ Microbiol, 14, 3188-3202 (2012)
18. Henche AL, Koerdt A, Ghosh A & Albers SV. Influence of cell surface structures on crenarchaeal biofilm formation using a thermostable green fluorescent protein. Environ Microbiol 14, 779-793 (2012)
19. Lassak K, Ghosh A & Albers SV. Diversity, assembly and regulation of archaeal type IV pili-like and non-type- IV pili-like surface structures. Res Microbiol, 163, 630-644 (2012)
20. Lassak K, Neiner T, Ghosh A, Klingl A, Wirth R & Albers SV. Molecular analysis of the crenarchaeal flagellum. Mol Microbiol, 83, 110-124 (2012)
21. Koerdt A, Jachlewski S, Ghosh A, Wingender J, Siebers B & Albers SV. Complementation of Sulfolobus solfataricus PBL2025 with an alpha-mannosidase: effects on surface attachment and biofilm formation. Extremophiles, 16, 115-125 (2012)
22. Ray R, Ghosh A, Bera A, Dutta N, Chattopadhyay DJ & Chakrabarti K. Analysis of differentially expressed transcripts in jute upon fungal infection and beta-amino butyric acid treatment. Physiol Mol Plant Physiol, 76, 59-66 (2011)
23. Ghosh A, Hartung S, van der Does C, Tainer JA & Albers SV. Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding. Biochem J, 437, 43-52 (2011)
24. Pohlschroder M, Ghosh A, Tripepi M & Albers SV. Archaeal type IV pilus-like structures-evolutionarily conserved prokaryotic surface organelles. Curr Opin Microbiol, 14, 357-363 (2011)
25. Ghosh A & Albers SV. Assembly and function of the archaeal flagellum. Biochem Soc Trans, 39, 64-69 (2011)
26. Basu S, Roy A, Ghosh A, Bera A, Chattopadhyay D & Chakrabarti K. Arg(235) is an essential catalytic residue of Bacillus pumilus DKS1 pectate lyase to degum ramie fibre. Biodegradation, 22, 153-161 (2011)
27. Ghosh A & Chattopadhyay D. Feather-degrading enzymes and their prospective applications. Advances in Bioprocesses in Food Industries, Vol IV by Soccol et. al. published by AsiaTech Publisher Inc., (ISBN: 9788187680284) (2011)
28. Ghosh A, Dey N, Bera A, Tiwari A, Sathyaniranjan K, Chakrabarti K & Chattopadhyay D. Culture independent molecular analysis of bacterial communities in the mangrove sediment of Sundarban, India. Saline Systems, 6,1 (2010)
29. Ghosh A, Chakrabarti K & Chattopadhyay D. Cloning of feather-degrading minor extracellular protease from Bacillus cereus DCUW: dissection of the structural domains. Microbiology, 155, 2049-2057 (2009)
30. Barua S, Tripathi S, Ghosh A, Chakraborty A, Ghosh S & Chakrabarti, K. Studies on Non-symbiotic Diazotropic Bacterial Population of the saline Soils of Sundarbans. J Pure Appl Microbiol, 2, 355-364 (2008)
31. Ghosh A, Chakrabarti K & Chattopadhyay D. Degradation of raw feather by a novel high molecular weight extracellular protease from newly isolated Bacillus cereus DCUW. J Ind Microbiol Biotechnol, 35, 825-834 (2008)
32. Basu S, Ghosh A, Bera A, Saha MN, Chattopadhyay D & Chakrabarti K. Thermodynamic characterization of a highly thermoactive extracellular pectate lyase from a new isolate Bacillus pumilus DKS1. Bioresource Technology, 99, 8088-8094 (2008)
33. Sinan M, Panda M, Ghosh A, Dhara K, Fanwick PE, Chattopadhyay DJ & Goswami S. Mild synthesis of a family of planar triazinium cations via proton-assisted cyclization of pyridyl containing azo compounds and studies on DNA intercalation. J American Chem Soc, 130, 5185-5193 (2008)
34. Saha B, Singh AK, Ghosh A & Bal M. Identification and characterization of a vancomycin-resistant Staphylococcus aureus isolated from Kolkata (South Asia). J Med Microbiol, 57, 72-79 (2008)
35. Ghosh A, Basu S, Datta H & Chattopadhyay D. Evaluation of polymerase chain reaction-based ribosomal DNA Sequencing technique for the diagnosis of mycotic keratitis. Am J Ophthalmol, 144, 396-403 (2007)
36. Ghosh A, Maity B, Chakrabarti K & Chattopadhyay, D. Bacterial diversity of east calcutta wet land area: Possible identification of potential bacterial population for different biotechnological uses. Microb Ecol, 54, 452-459 (2007)
- Selected as the Ramanujan Fellow by Department of Science and Technology (DST), India., 2013
- Selected as UGC-Assistant Professor through UGC-Faculty Recharge Program (UGC-FRP) by University Grant Commission (UGC). , 2012
- Recipient of Max Planck Postdoctoral Fellowship , 2008-2012
- Recipient of FEMS Congress Grant for Young Scientists from Federation of European Microbiological Society (FEMS) at the 4th FEMS Congress of European Microbiologists at PALEXPO, Geneva, Switzerland, 2011
- Recipient of Carl Storm International Diversity Fellowship for attending the Gordon Research Conferences: Structural, Functional, and Evolutionary Genomics at Wellcome Trust Conference Centre, Hinxton, Cambridge, United Kingdom, 2007
Bose Institute (MSc--‐PhD): Biophysical techniques (Chromatography), Prokaryotic Molecular Biology, Microbial Nutrition (Methanogenesis); WBUT, Kolkata (M Tech/M Sc-PhD): Microbial Nutrition, Cell Biology; Jogamaya Devi College, Calcutta University (M Sc): Genomics and proteomics; Bose Institute, Kolkata (PhD coursework): Introduction to Electron Microscopy.
- Chandrima Bhattacharyya (INSPIRE Fellow-Adhoc)
- Shayantan Mukherji (UGC-Adhoc)
- Mausam Roy (UGC-Adhoc)
- Sayandeep Gupta (CSIR-Project Fellow)
- Dr. Somi Patranabis (DBT Postdoctoral Fellow)
- Dhritiman Dey (WB DBT-Project Fellow)
1. Dr. Ivy Mallick (WB DBT-SRA; 2015-2016)
Opening for prospective graduate Students
Students with a very keen interest in Molecular Biology of Archaea and Microbial Genomics may contact PI directly at Abhrajyoti.email@example.com for any openings in the laboratory. It is also expected for a prospective student to have Biochemistry/Microbiology and/or Biotechnology in their undergraduate studies.
Opening for Postdocs
Prospective postdoctoral fellows are expected to be well-versed with molecular cloning, protein purification and other biochemical/microbiological techniques and are enthusiastic about learning structural and functional genomics and proteomics. Fellows are also expected to apply for an independent funding from different agencies like DST, DBT etc.
Project Assistantship/Summer training/Coursework training
There is no possibility of a Project Assistant position at this
For summer training, Bose Institute uses a centralized procedure and is advertised in the Institute Web-page (Advertisements section). Prospective trainees are requested to apply against that advertisement. They may also express their interest to do the training in our lab by writing directly to PI. However, please note that NO STUDENT CAN BE ACCEPTED for training unless they are selected through the centralized system.