Subhrangsu Chatterjee

Subhrangsu Chatterjee
Associate Professor

Previous appointments:

Postdoctoral Fellow, Department of Biochemistry, University of Alberta, Alberta, Canada (2008-2011)

Ramanujan Fellow (DST, Govt of India), Department of Biophysics, Bose Institute, Kolkata (2011-2016)

Associate Professor, Department of Biophysics, Bose Institute, Kolkata (2016-till date)

Research interests:

The main objective of our research is to understand the supercoiling of DNA structure in the chromosome and try to cultivate the importance of nucleic acid structural dynamics and breathing in a conformational hyperspace which can augment or deplete tumorigenesis. 

Contact:

Address: Department of Biophysics
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: subhro_c[at]jcbose.ac.in
Phone: +91-33-25693340

Research:

Publications:

Selected Publication: (till date)

56. Promoter G-quadruplex favors the epigenetic reprogramming-induced atypical expression of ZEB1 in cancer cells Anindya Dutta, Nilanjana Maji, Pallabi Sengupta, Nilanjan Banerjee , Swarnali Kar, Gopeswar Mukherjee , Subhrangsu Chatterjee*, Moitri Basu*. (2021, Accepted in BBA General subjects).  IF= 3.6

55. Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping," (i-science-D-20-02410R2). Mukherjee et. al. Corresponding Author (2021, Accepted in iScience, Cell Press). IF= 4.7

54. An alternative sigma factor of Staphylococcus aureus interacts with the cognate anti-sigma factor primarily using its domain Debabrata Sinha, Debasmita Sinha, Anindya Dutta, Tushar Chakraborty, Rajkrishna Mondal, Soham Seal, Asim Poddar, Subhrangsu Chatterjee, and Subrata Sau* Biochemistry 2021, 60, 135−15.

53. The Molecular Tête-à-tête between G-Quadruplex and I-motif in Human Genome.Pallabi Sengupta, Debopriya Bose and Subhrangsu Chatterjee*. ChemBioChem 2021, 22, 1–22 IF= 2.6

52. A conserved arginine residue in a staphylococcal anti-sigma factor is required to preserve its kinase activity, structure, and stability. Debasmita Sinha , Debabrata Sinha , Nilanjan Banerjee , Priya Rai , Soham Seal , Tushar Chakraborty, Subhrangsu Chatterjee, Subrata Sau. J Biomol Struct Dyn. 2020 Dec 24;1-15.

51. Immune Response and possible therapeutics in COVID-19. Anindya Dutta$, Ananya Roy$, Laboni Roy$, Samit Chattopadhyay* and Subhrangsu Chatterjee*. RSC Advances 10.1039/D0RA08901J RSC Adv., 2021, 11, 960-977.IF =3.1

50. Long Noncoding RNA in Cancer Immunity:a new avenue in Drug Discovery. Anindya Dutta, Ananya Roy and Subhrangsu Chatterjee*. Drug Discovery Today, Volume 26, Issue 1, January 2021, Pages 264-272 IF=7.3

49.Stemness factor represses SMAR1 to bestow drug resistance in cancer stem cells: Reversal by Aspirin. A. Bhattacharya.S Mukherjee, P Khan, S Banerjee, A Dutta, N Banerjee, D Sengupta, U Basak, S Chakraborty, A Dutta, S Chattopadhyay, K Janan, DK Sarkar, S Chatterjee and T Das*.Science Signaling. 2020, 13(654):6077.

48. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Pallabi Sengupta, Subhrangsu Chatterjee* Biochim Biophys Acta Gen Subj. 2020 Sep;1864(9):129649. IF=4.0

47. De Novo designed 13-mer hairpin-peptide arrests insulin and inhibits its aggregation: role of OH–π interactions between water and hydrophobic amino acids. Meghomukta Mukherjee,a Nilanjan Banerjeea and  Subhrangsu  Chatterjee*RSC Adv., 2020,10, 14991-14999. IF= 3.1

46.TGFβ mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1. Arnab Sarkar 1, Ashikur Rahaman 1, Ipsita Biswas 1, Gopeswar Mukherjee 2, Subhrangsu Chatterjee 3, Shamee Bhattacharjee 1, Deba Prasad Mandal. J Cell Physiol. 2020 Feb 4. doi:10.1002/jcp.29614 IF=5.4

45. Solute carrier proteins and c-Myc: a strong connection in cancer progression. Panda S, Banerjee N, Chatterjee S*. Drug Discov Today. 2020 May;25(5):891-900. IF=7.3

44.Tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin An expression.Parul Dutta, Sehbanul Islam, SrinadhChoppara, PallabiSengupta, Anil Kumar, Avinash Kumar, Mohan R Wani, Subhrangsu Chatterjee, and Manas Kumar Santra*.JBC 2019 2019 Oct 11;294(41):14879-14895. IF=4.1

43.SMAR1favorsimmunosurveillance of cancer cells by modulating calnexin and MHC I expression. Dr MilindThube, Dr AftabAlam, Dr AshisMukhopadhyay, Miss Rini Roy, Mr Nilanjan Banerjee, Miss TanayaRoychowdhury, Mr. DevrajMogare, Dr. NandarajTaye, Mr Vibhuti Kumar Shah, Dr. JayatiMullick, Dr. Subhrangsu Chatterjee, Dr. Rittwika Bhattacharya, Miss Richa Pant, Dr. Sonal Patel, Professor SamitChattopadhyay, Neoplasia, 2019, 21,10, 945-62. IF=3.8

42. 4'-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading. Nawale GN, Bahadorikhalili S, Sengupta P, Kadekar S, Chatterjee S, Varghese OP.ChemCommun (Camb). 2019,55, 9112-9115.IF=6.7

41.Enhancement of ABA sensitivity through the conditional expression of ARF10 gene in Brassica juncea exhibit fertile plants with tolerance against Alternariabrassicicola. Mukherjee A, Mazumder M, Jana J, Srivasatava AK, Mondal B, De A, Ghosh S, Saha U, Bose R, Chatterjee S, Dey N, Basu D.Mol Plant Microbe Interact.2019 Jun 11. DOI: 10.1094/MPMI-05-19-0132-R. IF = 3.6

40.Truncated G-Quadruplex Isomers Cross-Talk with the Transcription Factors To Maintain Homeostatic Equilibria in c-MYC Transcription.Sengupta P, Bhattacharya  A, Sa G, Das T, Chatterjee S*.Biochemistry. 2019 Apr 16;58(15):1975-1991. IF=3.0

39. Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA- mediated tumor-angiogenesis.Kajal K, Panda AK, Bhat J, Chakraborty D, Bose S, Bhattacharjee P, Sarkar T, Chatterjee S, Kar SK, Sa G. Sci Rep. 2019 Mar 11;9(1):4073. DOI: 10.1038/s41598-019-40626-2.IF=4.2

38. Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells. Sengupta P, Banerjee N, Roychowdhury T, Dutta A, Chattopadhyay S, Chatterjee S*.Nucleic Acids Res. 2018 Nov 2;46(19):9932-9950.doi: 10.1093/ nar /gky824. IF=11.6

37. SMAR1 inhibits Wnt/β-catenin signaling and prevents colorectal cancer progression. Nataraj Taye , AftabAlam , SuvankarGhorai , DeyaChatterji , ApoorvaParulekar , DevrajMogare , Snahlata Singh, Pallabi Sengupta, Subhrangsu Chatterjee, Manoj Bhat, Manassantra, Prabhakar Salunkhe, Susan Finston, Sami Chattopadhyay*. Oncotarget. 2018 Apr 20;9(30):21322-21336. DOI: 10.18632/oncotarget.25093.IF=5.4

36. Spatial Position Regulates Power of Tryptophan: Discovery of a Major-Groove- Specific Nuclear-Localizing, Cell-Penetrating Tetrapeptide. BhuniaD, Mondal P, Das G, Saha A, Sengupta P, Jana J, Mohapatra S, Chatterjee S, Ghosh S. J Am Chem Soc. 2018 Feb 7;140(5):1697-1714.IF=14.3

35.Small Molecule impedes Insulin fibrillation; a new role of Phenothizine Derivative.Meghomukta Mukherjee, Jagannath Jana and Subhrangsu Chatterjee*. Chemistry Open 2018,7,68–79.IF=3.0

34.LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness.Samarjit Jana2,*, Jagannath Jana1,*, Kartick Patra2, Soma Mondal1, Jyotsna Bhat1, Arnab Sarkar2, Pallabi Sengupta1, Anindya Biswas3, Meghomukta Mukherjee1, Satya Prakash Tripathi5, Rahul Gangwal5, Joyita Hazra6, Abhay T. Sangamwar7 Gopeswar Mukherjee4, Shamee Bhattacharjee2*, Deba Prasad Mandal2* and SubhrangsuChatterjee*.Oncotarget, 2017 Nov 17;8(66):110234-110256.IF=5.4

33.InSilico Screening and Binding Characterization of Small Molecules toward a G- Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene. Bhat, Jyotsna; Mondal, Soma; Sengupta, Pallabi; Chatterjee, Subhrangsu. ACS Omega (2017), 2(8), 4382-4397.IF=2.58

32.G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment.Sengupta, Pallabi; Chattopadhyay, Samit; Chatterjee, Subhrangsu. Drug Discovery Today (2017), 22(8), 1165-1186.IF=7.3

31.Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex. Jana, Jagannath; Sengupta, Pallabi; Mondal, Soma; Chatterjee, Subhrangsu. RSC Advances (2017), 7(34), 20888-20899.IF=3.4

30.Chelerythrine down-regulates expression of VEGFA, BCL2 and KRAS by arresting G-quadruplex structures at their promoter regions.Jana, Jagannath; Mondal, Soma; Bhattacharjee, Payel; Sengupta, Pallabi; Roychowdhury, Tanaya; Saha, Pranay; Kundu, Pallob; Chatterjee, Subhrangsu. Scientific Reports (2017), 7, 40706.IF=5.4

29.Functional characterization of Rorippa indica defensin and its efficacy against Lipaphiserysimi.Sarkar, P.; Jana, J.; Chatterjee, S.; Sikdar, S. R., Springerplus2016,5, 511.

28.G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.Saha, Taniya; Guha, Deblina; Manna, Argha; Panda, Abir Kumar; Bhat,Jyotsna; Chatterjee, Subhrangsu; Sa, Gaurisankar. Scientific Reports (2016), 6, 32626. IF=5.4

27.Cancer chemotherapeutic agent/formulation, manufacture and use thereof. U.S. Pat. Appl. Publ. (2016), US 20160023996 A1 20160128. Chatterjee et. Al                       

26.Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signaling pathways for induction of apoptosis in human breast carcinoma cells.Supriya Chakraborty, Swatilekha Ghosh, Bhaswati Banerjee, Abhishek Santra, JyotsnaBhat, ArghyaAdhikary, Subhrangshu Chatterjee, Anup K. Misra, Parimal C. Sen*. Apoptosis (2016),21(10),1106-1124.IF=3.8

25.Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-Mediated deacetylation of Sam68.Kiran Kumar Nakka, Nidhi Chaudhary, Shruti Joshi, JyotsnaBhat, Subhrangsu Chatterjee, Renu Malhotra, Abhijit De, Manas Kumar Santra, F. Jeffrey Dilworth and SamitChattopadhyay* (Proc Natl Acad Sci U S A). 2015 Jun 30;112(26):E3374-83) IF =9.81

24.Discovery and Structural Characterization of G-quadruplex DNA in Human Acetyl-CoA Carboxylase Gene Promoters: Its Role in Transcriptional Regulation and as a Therapeutic Target for Human Disease.Kaulage M, Maji B, Bhat J, Iwasaki Y, Chatterjee S, Bhattacharya S, Muniyappa K. J Med Chem. 2016 May 26;59(10):5035- 50.IF=6.3

23.Plant Alkaloid Chelerythrine Induced Aggregation of Human Telomere Sequence- A Unique Mode of Association between a Small Molecule and a Quadruplex.Ghosh S, Jana J, Kar RK, Chatterjee S*, Dasgupta D*. Biochemistry. 2015 Feb 3;54(4):974-86. DOI: 10.1021/bi501117x.Epub 2015 Jan 21 IF= 3.0

22. Reverse Watson–Crick G–G base pair in G-quadruplex formation†Soma Mondal, Jyotsna Bhat, Jagannath Jana, Meghomukta Mukherjee and Subhrangsu Chatterjee* Mol. BioSyst., 2016,12, 18-22. IF= 3.0

21. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiationNidhi Chaudhary, Kiran Kumar Nakka, Lakshminarasimhan Pavithra, Jyotsna Bhatt, Subhrangsu Chatterjee and SamitChattopadhyay* Cell Death and Disease, 2014 Oct 9, e1447. IF= 5.4

20.Protective effect of antioxidant-rich aqueous curry leaf (Murrayakoenigii) extract against gastro-toxic effects of piroxicam in male Wistar rats.Firdaus SB, Ghosh D, Chattopadhyay A, Dutta M, Paul S, Jana J, Basu A, Bose G, Lahiri H, Banerjee B, Pattari S, Chatterjee S, Jana K, Bandyopadhyay D.Toxicol Rep.2014 Jul 2;1:987-1003. IF=2.6

19.Double GC: GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High-Resolution NMR Study. Ghosh A, Kar RK, Krishnamoorthy J, Chatterjee S*, Bhunia A*. ChemMedChem. 2014 Sep;9(9):2059-64. doi: 10.1002/cmdc.201402238. Epub 2014 Jul 30 IF= 3.0

18. Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy.Anirban Ghosh, Rajiv Kumar Kar, Jagannath Jana, AbhijitSaha, Balakrishna Jana, Janarthanan Krishnamoorthy, Dinesh Kumar, SurajitGhosh*, Dr.SubhrangsuChatterjee* and Dr. AnirbanBhunia*ChemMedChem. Volume 9, Issue 9, pages2052–2058, September 2014. IF= 3.0

17.Sequence context-induced antimicrobial activity: insight into lipopolysaccharide permeabilization. Ghosh A, Datta A, Jana J, Kar RK, Chatterjee C, Chatterjee S*, Bhunia A*. MolBiosyst. 2014 Jun;10(6):1596-612. IF= 3.2

16.Use of Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process:  A study by High and Low-Resolution Spectroscopy (2013) Victor Banerjee1+, Rajiv K. Kar2+, AritreyeeDatta2, Krupakar Parthasarathi3, Subhrangsu Chatterjee2, Kali P. Das1*, and Anirban Bhunia2*. PLoS One. 2013 Aug 29;8(8):e72318 IF= 4.09

15.Human cathelicidin peptide LL37 binds telomeric G-quadruplex. Jana J, Kar RK, Ghosh A,Biswas A, Ghosh S, Bhunia A*, Chatterjee S* (2013) Mol. Biosyst. Vol. 9: pp 1833-6. IF=3.35

14. Novel G-quadruplex stabilizing agents: in-silico approach and dynamics. Rajiv Kumar Kar,PriyankaSuryadevaraJagannath Jana, AnirbanBhunia* and Subhrangsu Chatterjee* JBSD 2013. 31, 12, 1497-1518. IF=4.99

13.Solution Structure, Dynamics, and Ice Growth Inhibitory Activity of Peptide Fragments Derived from Glaciozymaantarctica Antifreeze Protein.Syed Hussinien H. Shah1, , Rajiv K.Kar2, , Mohammad F. Zulkifli1, MohdBasyaruddin A. Rahman1, Abdul Munir A. Murad3, Nor M. Mahadi3, Mahiran Basri1, Raja Noor Zaliha A. Rahman4, Abu B. Salleh3, SubhrangsuChatterjee2,*, Bimo A. Tejo1,* and Anirban Bhunia2,* PLoS One. 2012;7(11):e49788. IF=4.09

12.Applications of saturation transfer difference NMR in biological systems.Bhunia A, Bhattacharjya S, Chatterjee S. Drug Discovery Today 2011 Volume 17, Numbers 9/10, page 505-513. IF= 6.55

11.Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies.Olivier Julien†, Subhrangsu Chatterjee†, Trent C. Bjorndahl, Braden Sweeting, Sandipta Acharya, ValentynaSemenchenko, AvijitChakrabartty, Emil F. Pai, David S. Wishart, Brian D. Sykes*, and Neil R. Cashman (co-first author) Biochemistry. 2011 50(35):7536-45. IF=3.0

10.Solution Structure of a DNA Duplex Containing the Potent Anti-poxvirus Agent Cidofovir. Olivier JulienI, James R. BeadleI, ,Wendy C. Magee, Subhrangsu Chatterjee , Karl Y. Hostetler, David H. Evans, and Brian D. Sykes. J Am Chem Soc. 2011;133(7):2264-74. IF=14.3

9.Differential stability of the bovine prion protein upon urea unfolding.Olivier Julien, S.Chatterjee, Angela Thiessen, Steffen P. Graether, and Brian D. Sykes*, Protein Science 2009, vol 18, 2172-82.IF=3.0

8. High-Quality oligo-RNA Synthesis using the New 2'-OTEM Protecting Group by Selectively Quenching the Addition of p-Tolyl Vinyl Sulphone to Exocyclic Amino Functions.C. Zhou, D.Honcharenko, W. Pathmasiri, S.Chatterjee, and J. Chattopadhyaya, Canadian Journal of Chemistry (2007), 85(4), 293-301. IF=1.2

7. Chemical and Structural Implications of 1',2'- versus 2',4'-Conformational Constraints in the Sugar Moiety of Modified Thymine Nucleosides.O. Plashkevych*,S. Chatterjee, D.HoncharenkoW.Pathmasiri, and J.Chattopadhyaya*, Journal of Organic Chemistry (2007), 72(13), 4716-4726. [O. Plashkevych, co-supervisor]***IF=4.2

6.The chemical nature of the 2'-substituent in the pentose-sugar dictates the pseudo-romantic character of the nucleobase (pKa) in DNA/RNA.Chatterjee, Subhrangsu; Pathmasiri, Wimal;Plashkevych, Oleksandr; Honcharenko, Dmytro; Varghese, Oommen P.; Maiti, Mohitosh; Chattopadhyaya, Jyoti. Organic &Biomolecular Chemistry (2006), 4(9), 1675-1686.IF=3.5

5.Non-identical electronic characters of the internucleotide phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds. Barman, Jharna; Acharya, Sandipta ; Zhou, Chuanzheng; Chatterjee, Subhrangsu, Engstroem, Aake; Chattopadhyaya, Jyoti. Organic & Biomolecular Chemistry (2006), 4(5), 928- 941.IF=3.5

4.Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions-an NMR structure and hydration study. Isaksson, J.; Plashkevych, O.; Pradeepkumar, P.I.; Chatterjee, S.; Barman, J.; Pathmasiri, W.; Shrivastava, P.; Petit, C.; Chattopadhyaya, J. Journal of Biomolecular Structure & Dynamics (2005), 23(3), 299-330. IF= 4.9

3. The 5-Me of thymine (T) interaction with the neighboring nucleobases dictates the relative stability of inconsequential DNA-RNA hybrid duplexes. Chatterjee, Subhrangsu; Pathmasiri, Wimal; Chattopadhyaya, Jyoti. Organic & Biomolecular Chemistry (2005), 3(21), 3911-3915. IF=3.5

2.SignificantpKa Perturbation of Nucleobases Is an Intrinsic Property of the Sequence Context in DNA and RNA.Acharya, Sandipta; Barman, Jharna; Cheruku, Pradeep; Chatterjee, Subhrangsu; Acharya, Parag; Isaksson, Johan; Chattopadhyaya, Jyoti. Journal of the American Chemical Society(2004), 126(28), 8674-8681. IF=14.3

1. Measurement of NucleobasepKa Values in Model Mononucleotides Shows RNA- RNA Duplexes To Be More Stable than DNA-DNA Duplexes.Acharya, P.; Cheruku, P.;Chatterjee, S.; Acharya, S.; Chattopadhyaya, J. Journal of the American Chemical Society (2004), 126(9), 2862-2869Oommen P.; Maiti, Mojitos; Chattopadhyaya, Jyoti. Organic & Biomolecular Chemistry (2006), 4(9), 1675-1686. IF=3.5


Patent:  A cancer Chemotherapeutic agent /Formulation, Manufacture and Use thereof

(Indian Full filing: 1120/KOL/2012 and PCT claim: PCT/IN2013/000593)-

Inventors:

Subhrangsu Chatterjee*(PI, BI), Anirban Bhunia(Co-PI, BI), Debaprasad Mondal (Co-PI, WBSU), Shamee Bhattacharya (Co-PI, WBSU).

 

US patent is granted: US 9682926 B2

Australian Patent is granted: AU2018201532B2

European Patent is granted: EP2900234B1

 

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Recognition:

    Teaching:

    Students:

    Image Name Designation Department Campus Contact number Email
    profile image Debopriya Bose Junior Research Fellow Biophysics Centenary 25693218
    profile image OISHIKA CHATTERJEE Junior Research Fellow Biophysics Centenary 25693340

    Former:

    1. Dr. Jagannath Jana  (Postdoctoral Fellow at Institute of Curie, Paris, France)

    2. Dr. Jyotsna Bhat (Marie Curie Fellow  )

    3. Dr. Soma Mandal (DBT Research Assistant at SINP, Kolkata) 

    4. Ms. Meghomukta Mukherjee ( UT South Western USA)( Thesis Submitted)

    5. Ms. Pallabi Sengupta (Umea University, Sweden) ( Thesis Submitted)

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